GCM2 Activators
The GCM2 gene encodes a transcription factor called Glial Cells Missing 2 (GCM2), which holds a pivotal role in the intricate orchestration of gene expression and cellular processes, primarily within the realm of developmental biology and tissue differentiation. These activators encompass a diverse array of substances, ranging from small synthetic molecules to natural compounds, and they function by interacting with GCM2 directly or indirectly, thereby exerting a profound influence on its transcriptional activity and the subsequent downstream effects on gene expression. At the heart of its biological significance, GCM2 stands out for its critical involvement in the development and differentiation of trophoblast cells-a specialized cell type that is indispensable for the formation and proper functioning of the placenta during embryogenesis. GCM2 serves as a potent transcriptional regulator by binding specifically to DNA sequences known as GCM response elements (GCMREs), thereby orchestrating the activation or repression of target genes crucial for placental development.
GCM2 activators, as the name suggests, are compounds that possess the remarkable ability to enhance the transcriptional activity of GCM2. In practical terms, this means that they facilitate the precise and finely-tuned regulation of genes that are fundamental for placental morphogenesis and function.
The mechanisms through which GCM2 activators operate can be multifaceted and intricate, but they frequently involve direct interactions with the GCM2 protein itself or its associated co-factors. These compounds can act by influencing the structural conformation of GCM2, promoting its affinity for DNA binding, or enhancing its stability within the cellular milieu. As a result, GCM2 activators effectively elevate the transcriptional activity driven by GCM2, enabling the precise control of gene expression in the context of placental development and beyond. Understanding the intricacies of GCM2 activators holds significant scientific importance as it advances our comprehension of the delicate and highly regulated processes underpinning placental development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Modulates cytokine production by inhibiting TNF-α; Inhibits NF-κB signaling leading to gene expression changes. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Disrupts mitochondrial function; Activates p53 to influence gene expression related to apoptosis and cell cycle. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Modulates gene expression via AMPK activation and various signaling pathways. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
Acts as a ligand for retinoic acid receptors (RARs), influencing transcription related to cell differentiation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Modulates gene expression by influencing various signaling pathways, including NF-κB. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts as a ligand for nuclear retinoic acid receptors (RARs), regulating gene expression related to differentiation. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Activates PKC and NF-κB signaling, impacting gene expression in immune responses and cell growth regulation. | ||||||