GCKR Antibody (G-6): sc-74544

GCKR Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects glucokinase regulatory protein (GCKR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GCKR plays a crucial role in the regulation of glucokinase, which is essential for maintaining glucose homeostasis in the body. By modulating the activity of glucokinase, GCKR influences insulin secretion in response to glucose levels, making GCKR a vital component in the pathophysiology of diabetes. GCKR is primarily located in the liver and pancreatic tissues, where GCKR acts as a regulatory checkpoint for glucose metabolism. Understanding the function and regulation of GCKR is important, as mutations or dysregulation of GCKR can lead to conditions such as maturity onset diabetes of the youth (MODY), highlighting GCKR′s significance in metabolic health. Anti-GCKR antibody (G-6) provides a valuable tool for researchers studying the intricate mechanisms of glucose regulation and its implications in diabetes and other metabolic disorders.

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GCKR Antibody (G-6) References:

1. Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain.  |  Alvarez, E., et al. 2002. J Neurochem. 80: 45-53. PMID: 11796742
2. Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.  |  Petta, S., et al. 2014. PLoS One. 9: e87523. PMID: 24498332
3. Role of glucokinase in the subcellular localization of glucokinase regulatory protein.  |  Jin, L., et al. 2015. Int J Mol Sci. 16: 7377-93. PMID: 25849650
4. Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.  |  Park, JM., et al. 2015. Sci Rep. 5: 17395. PMID: 26620281
5. Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.  |  Kaushik, A. and Kaushik, M. 2019. Curr Diabetes Rev. 15: 205-212. PMID: 30039763
6. Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes.  |  Paliwal, A., et al. 2024. Mini Rev Med Chem. 24: 674-688. PMID: 37612862
7. ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.  |  Singh, C., et al. 2024. Cell Metab. 36: 144-158.e7. PMID: 38101397
8. Glucokinase regulatory protein rs780094 polymorphism is associated with type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease, and nephropathy.  |  Al Madhoun, A. 2024. World J Diabetes. 15: 814-817. PMID: 38766433
9. Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency.  |  Buziau, AM., et al. 2024. Mol Metab. 87: 101984. PMID: 38972375
10. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.  |  Warner, JP., et al. 1995. Mamm Genome. 6: 532-6. PMID: 8589523

The preferred GCKR antibody is GCKR Antibody (B-9): sc-166841.