GCAP2 Antibody (6D433): sc-71137

GCAP2 Antibody (6D433) is a mouse monoclonal IgG2a antibody that detects guanylate cyclase-activating protein 2 (GCAP2) in bovine samples through western blotting (WB). GCAP2 plays a crucial role in the regulation of phototransduction in the retina, specifically in cone photoreceptors, where GCAP2 is involved in the recovery phase following light exposure. GCAP2 is essential for maintaining proper levels of cyclic guanosine monophosphate (cGMP), which is vital for photoreceptor function and visual signaling. GCAP2 is primarily localized in the outer segments of photoreceptors, where GCAP2 interacts with guanylate cyclase to modulate its activity in response to changes in intracellular calcium levels. Notably, GCAP2 is a product of a gene duplication event related to GCAP1, and while both proteins share over 90% sequence similarity, GCAP2 is uniquely expressed in the retina, highlighting GCAP2′s specialized function in visual processing. The genes encoding GCAP1 and GCAP2 are located on human chromosome 6p21.1, underscoring their evolutionary relationship and importance in retinal health. Anti-GCAP2 antibody (6D433) is an invaluable tool for researchers studying retinal physiology and the molecular mechanisms underlying vision.

The preferred GCAP2 antibody is GCAP2 Antibody (G-10): sc-166056.