GC-C Antibody (537): sc-100302

GC-C Antibody (537) is a mouse monoclonal IgG2b kappa light chain antibody that detects the GC-C protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GC-C antibody (537) is available as a non-conjugated format. GC-C protein, also known as guanylate cyclase C, plays a crucial role in gastrointestinal physiology by acting as a receptor for heat-stable enterotoxins produced by certain pathogenic strains of E. coli, which can lead to severe secretory diarrhea. GC-C (537) antibody targets proteins located on the plasma membrane of intestinal epithelial cells, where GC-C is essential for mediating the effects of guanylin and uroguanylin, peptides that help regulate fluid and electrolyte balance in response to dietary salt intake. GC-C includes an extracellular domain that binds ligands, a single transmembrane domain, and a cytoplasmic region with a kinase-like domain and a catalytic domain, which is vital for function in cGMP signaling pathways. GC-C monoclonal antibody (537) recognizes proteins that promote cGMP accumulation upon ligand binding, significant for maintaining intestinal homeostasis and responding to pathological conditions.

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GC-C Antibody (537) References:

1. Guanylate cyclase and the.NO/cGMP signaling pathway.  |  Denninger, JW. and Marletta, MA. 1999. Biochim Biophys Acta. 1411: 334-50. PMID: 10320667
2. In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis.  |  Condorelli, P. and George, SC. 2001. Biophys J. 80: 2110-9. PMID: 11325714
3. Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C.  |  Ghanekar, Y., et al. 2003. Eur J Biochem. 270: 3848-57. PMID: 12950269
4. Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.  |  Ghanekar, Y., et al. 2004. Biochem J. 379: 653-63. PMID: 14748740
5. Cardiac and intestinal natriuretic peptides: insights from genetically modified mice.  |  Kuhn, M. 2005. Peptides. 26: 1078-85. PMID: 15911075
6. Enterotoxin/guanylin receptor type guanylyl cyclases in non-mammalian vertebrates.  |  Nakauchi, M. and Suzuki, N. 2005. Zoolog Sci. 22: 501-9. PMID: 15930822
7. Guanylate cyclase-C receptor activation: unexpected biology.  |  Brierley, SM. 2012. Curr Opin Pharmacol. 12: 632-40. PMID: 23131468
8. Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain.  |  Hannig, G., et al. 2014. Front Mol Neurosci. 7: 31. PMID: 24795564
9. Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.  |  Akieda-Asai, S., et al. 2018. Peptides. 99: 14-19. PMID: 29097254
10. Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders.  |  Waldman, SA. and Camilleri, M. 2018. Gut. 67: 1543-1552. PMID: 29563144
11. Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities.  |  Prasad, H., et al. 2022. Front Endocrinol (Lausanne). 13: 911459. PMID: 35846281
12. Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway.  |  Zhang, Y., et al. 2024. J Ethnopharmacol. 322: 117503. PMID: 38043755

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GC-C Antibody (537) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-GC-C Antibody (537) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GC-C Antibody (537) Specifications

Alternate Product Name: GC-C

Product Clone Name: 537

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 24-133

Epitope Target: GC-C

Epitope Species: human

Product Reactivity/Detection: GC-C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for GC-C Antibody (537): N/A