Date published: 2026-4-1

1-800-457-3801

SCBT Portrait Logo
Seach Input

Guanylate Cyclases Inhibitors

Santa Cruz Biotechnology now offers a broad range of Guanylate Cyclase Inhibitors for use in various applications. Guanylate cyclases are enzymes responsible for converting GTP into cyclic GMP (cGMP), a pivotal second messenger involved in numerous physiological processes, including vasodilation, phototransduction, and regulation of cellular growth and differentiation. Guanylate Cyclase Inhibitors are vital tools in scientific research, allowing researchers to explore the intricate signaling pathways regulated by cGMP and how these pathways influence cellular and systemic functions. By inhibiting guanylate cyclase activity, scientists can study the downstream effects of reduced cGMP levels, providing insights into the mechanisms by which cGMP modulates processes like smooth muscle relaxation, neural signaling, and response to environmental stimuli. These inhibitors are widely utilized in molecular biology, cardiovascular research, and neurobiology to investigate the role of cGMP in health and disease, particularly in understanding conditions where cGMP signaling is disrupted. The availability of these inhibitors has significantly advanced research in various fields, providing essential tools for dissecting the complex interactions within cGMP-mediated signaling networks. View detailed information on our available Guanylate Cyclase Inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BPIPP

325746-94-9sc-203852
sc-203852A
10 mg
50 mg
$189.00
$797.00
1
(1)

BPIPP acts as a potent modulator of guanylate cyclases, engaging in specific interactions that enhance the conversion of GTP to cGMP. Its structural features promote a unique binding affinity, optimizing enzyme conformation for increased catalytic activity. The compound's ability to influence reaction kinetics is notable, as it alters the rate of cGMP production, thereby impacting downstream signaling pathways. Additionally, BPIPP's diverse functional groups facilitate interactions with lipid membranes, potentially affecting cellular compartmentalization and signaling dynamics.

2-Chloroadenosine triphosphate sodium salt

49564-60-5sc-288070
5 µmol
$357.00
1
(0)

2-Chloroadenosine triphosphate sodium salt serves as a significant activator of guanylate cyclases, exhibiting a unique ability to stabilize enzyme-substrate complexes. Its distinct molecular structure allows for enhanced specificity in binding, which accelerates the conversion of GTP to cGMP. This compound also influences allosteric sites, modulating enzyme activity and altering the dynamics of intracellular signaling cascades. Furthermore, its ionic nature may enhance solubility and membrane permeability, impacting cellular interactions.

AG-1288

116313-73-6sc-200664
sc-200664A
10 mg
50 mg
$60.00
$311.00
(0)

AG-1288 functions as a potent modulator of guanylate cyclases, characterized by its ability to selectively interact with specific receptor sites. This compound promotes the formation of cGMP through a unique mechanism that involves the stabilization of transition states during the catalytic process. Its structural features facilitate rapid reaction kinetics, allowing for efficient signal transduction. Additionally, AG-1288's hydrophilic properties enhance its interaction with cellular membranes, influencing downstream signaling pathways.

NS 2028

204326-43-2sc-202743
5 mg
$149.00
1
(0)

NS 2028 acts as a selective modulator of guanylate cyclases, distinguished by its unique binding affinity for allosteric sites on the enzyme. This compound enhances cGMP synthesis by promoting conformational changes that optimize enzyme activity. Its kinetic profile reveals a remarkable rate of activation, contributing to robust signaling cascades. Furthermore, NS 2028's lipophilic characteristics enable effective membrane penetration, impacting cellular response mechanisms.