G_{β 1} Antibody (B-3): sc-515822

Gβ 1 Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects Gβ 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gβ 1 is a crucial component of the heterotrimeric G protein complex, which plays a vital role in transmitting signals from various cell surface receptors to intracellular effectors, thereby influencing numerous physiological processes. The Gβ subunits, including Gβ 1, are essential for regulating the activity of G protein α subunits and modulating signal transduction pathways. Notably, Gβ 1 interacts with Gγ subunits to form a functional Gβγ dimer, which is involved in activating downstream signaling pathways, including those mediated by phospholipase C and ion channels. Proper functioning of Gβ 1 and its interactions are critical for maintaining cellular responses to external stimuli, making Gβ 1 an important target for research in areas such as neurobiology and cardiovascular health. Gβ 1 is predominantly expressed in the brain, heart, and other tissues, highlighting its significance in various biological contexts.

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G_{β 1} Antibody (B-3) References:

1. Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.  |  Hiskens, R., et al. 2005. Biochem Biophys Res Commun. 337: 1038-46. PMID: 16225846
2. Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts.  |  de Wilde, A., et al. 2006. J Cell Physiol. 209: 786-801. PMID: 16972265
3. NMR-detected conformational exchange observed in a computationally designed variant of protein Gbeta1.  |  Crowhurst, KA. and Mayo, SL. 2008. Protein Eng Des Sel. 21: 577-87. PMID: 18586670
4. The rapid activation of N-Ras by alpha-thrombin in fibroblasts is mediated by the specific G-protein Galphai2-Gbeta1-Ggamma5 and occurs in lipid rafts.  |  Lents, NH., et al. 2009. Cell Signal. 21: 1007-14. PMID: 19250965
5. Dimer formation of a stabilized Gbeta1 variant: a structural and energetic analysis.  |  Thoms, S., et al. 2009. J Mol Biol. 391: 918-32. PMID: 19527728
6. Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations.  |  Bui, JM., et al. 2009. Biophys J. 97: 2513-20. PMID: 19883594
7. Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.  |  Okae, H. and Iwakura, Y. 2010. Dev Dyn. 239: 1089-101. PMID: 20186915
8. Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium.  |  Xu, H., et al. 2014. Dev Biol. 385: 316-27. PMID: 24201188
9. Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.  |  Khan, SM., et al. 2015. Cell Signal. 27: 1597-608. PMID: 25916507
10. RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration.  |  Haap-Hoff, A., et al. 2025. Immunol Cell Biol. 103: 73-92. PMID: 39607284

The preferred G_β antibody is G_β Antibody (H-1): sc-166123.