GATSL3 Antibody (A-6): sc-377114

GATSL3 (A-6) is a mouse monoclonal IgM kappa antibody that detects GATSL3 protein of mouse, rat and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP) and enzyme-linked immunosorbent assay (ELISA). Anti-GATSL3 antibody (A-6) is available as the non-conjugated form. GATSL3 (GATS-like protein 3) is a 329 amino acid protein that belongs to the GATS family. The gene encoding GATSL3 maps to human chromosome 22, which contains over 500 genes and about 49 million bases. Being the second smallest human chromosome, 22 contains a surprising variety of interesting genes. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia.

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GATSL3 Antibody (A-6) References:

1. Chromosome 22 workshop report.  |  Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
2. Disease genes and chromosomes: disease maps of the human genome. Chromosome 22.  |  Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
3. Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2.  |  Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
4. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.  |  Paylor, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 7729-34. PMID: 16684884
5. Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia.  |  Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
6. Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.  |  Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
7. BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.  |  Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
8. Deletion 22q11: spectrum of associated disorders.  |  Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GATSL3 Antibody (A-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GATSL3 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GATSL3 Antibody (A-6) Specifications

Alternate Product Name: GATSL3

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 127-155

Epitope Target: GATSL3

Epitope Species: human

Product Reactivity/Detection: GATSL3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GATSL3 Antibody (A-6): P: Blocking Peptide