GATAD2A Antibody (p66aF11A7): sc-81110
- GATAD2A Antibody (p66aF11A7) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of GATAD2A of human origin
- recommended for detection of GATAD2A of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GATAD2A Antibody (p66aF11A7). This work is in progress.
QUICK LINKS
GATAD2A Antibody (p66aF11A7) is a mouse monoclonal IgG1 antibody that detects GATAD2A in human samples through western blotting (WB) and immunoprecipitation (IP) applications. GATAD2A, also known as p66α, is a ubiquitously expressed and highly conserved protein that plays a crucial role in development by functioning as a key component of the NuRD (nucleosome remodeling and histone deacetylation) complex, which includes other important proteins such as MBD2, HDAC1, and HDAC2. This complex is vital for ATP-dependent chromatin remodeling and histone deacetylation, processes that are essential for regulating gene expression and maintaining cellular homeostasis. GATAD2A is characterized by its GATA-type zinc finger domain, which facilitates interaction with MBD2 and MBD3, leading to colocalization in nuclear speckles. This interaction enhances transcriptional repression mediated by MBD2 and promotes binding to histone tails, thereby influencing chromatin structure and gene accessibility. Notably, functional repressor activity of GATAD2A depends on post-translational modifications, specifically SUMOylation at Lys-30 and Lys-487, which are critical for transcriptional regulation. Anti-GATAD2A antibody (p66aF11A7) serves as an invaluable tool for researchers studying intricate mechanisms of gene regulation and chromatin dynamics in human cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GATAD2A Antibody (p66aF11A7) | sc-81110 | 100 µg/ml | $339.00 |