GATA-6 Antibody (3H3-H6-H11): sc-517554

GATA-6 Antibody (3H3-H6-H11) is a mouse monoclonal IgG antibody that detects GATA-6 protein of human origin by western blotting (WB) and immunoprecipitation (IP). GATA-6 Antibody (3H3-H6-H11) is available as a non-conjugated anti-GATA-6 antibody (3H3-H6-H11), providing researchers with a reliable tool for studying this important transcription factor. GATA-6 plays a crucial role in the regulation of gene expression during development, particularly in the heart, pancreas, and reproductive tissues. GATA-6 is essential for the differentiation and function of various cell types, including cardiac myocytes and pancreatic endocrine cells. GATA-6 is located primarily in the nucleus, where GATA-6 binds to specific DNA sequences to modulate transcription, making GATA-6 vital for proper cellular function and development. Dysregulation of GATA-6 has been implicated in various diseases, including congenital heart defects and diabetes, highlighting GATA-6′s significance in both developmental biology and disease pathology. The GATA family of transcription factors, which includes GATA-1, GATA-2, GATA-3, GATA-4, GATA-5, and GATA-6, share a conserved zinc finger DNA-binding domain, allowing these factors to interact with similar regulatory elements in target genes. Understanding the specific roles and interactions of GATA-6 can provide insights into the complex regulatory networks that govern cellular differentiation and function.

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GATA-6 Antibody (3H3-H6-H11) References:

1. Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development.  |  Kiiveri, S., et al. 2002. Endocr Res. 28: 647-50. PMID: 12530677
2. GATA-4 and GATA-6 transcription factors: expression, immunohistochemical localization, and possible function in the porcine ovary.  |  Gillio-Meina, C., et al. 2003. Biol Reprod. 68: 412-22. PMID: 12533404
3. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.  |  Dorfman, DM., et al. 1992. J Biol Chem. 267: 1279-85. PMID: 1370462
4. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis.  |  Lepore, JJ., et al. 2006. J Clin Invest. 116: 929-39. PMID: 16557299
5. The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.  |  Setogawa, T., et al. 2006. Biochem Biophys Res Commun. 343: 1186-90. PMID: 16580634
6. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.  |  Shureiqi, I., et al. 2007. FASEB J. 21: 743-53. PMID: 17167069
7. Adrenocortical tumorigenesis, luteinizing hormone receptor and transcription factors GATA-4 and GATA-6.  |  Vuorenoja, S., et al. 2007. Mol Cell Endocrinol. 269: 38-45. PMID: 17337116
8. Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa.  |  Haveri, H., et al. 2008. BMC Gastroenterol. 8: 9. PMID: 18405344
9. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.  |  Ko, LJ., et al. 1991. Mol Cell Biol. 11: 2778-84. PMID: 2017177
10. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.  |  Laverriere, AC., et al. 1994. J Biol Chem. 269: 23177-84. PMID: 8083222
11. DNA-binding specificities of the GATA transcription factor family.  |  Ko, LJ. and Engel, JD. 1993. Mol Cell Biol. 13: 4011-22. PMID: 8321208
12. The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.  |  Suzuki, E., et al. 1996. Genomics. 38: 283-90. PMID: 8975704

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GATA-6 Antibody (3H3-H6-H11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GATA-6 Antibody (3H3-H6-H11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GATA-6 Antibody (3H3-H6-H11) Specifications

Alternate Product Name: GATA6

Product Clone Name: 3H3-H6-H11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG kappa light chain

Amino Acids:

Epitope Target: GATA6

Epitope Species: human

Product Reactivity/Detection: GATA-6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GATA-6 Antibody (3H3-H6-H11): N/A

The preferred GATA-6 antibody is GATA-6 Antibody (F-3): sc-518050.