GATA-5 Antibody (D-5): sc-373684

GATA-5 Antibody (D-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects GATA-5 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GATA-5 Antibody (D-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GATA-5 plays a crucial role in the development and differentiation of various tissues, particularly in the heart and gastrointestinal tract, where GATA-5 is involved in regulating gene expression during embryonic development. This transcription factor belongs to the GATA family, characterized by a conserved zinc finger DNA-binding domain that binds to specific DNA sequences, influencing target gene transcription. GATA-5 regulates genes involved in heart morphogenesis and function, making GATA-5 essential for cardiac development. GATA-5 expression requires tight control for proper cardiac tissue development, highlighting GATA-5′s importance in normal physiology and potential pathologies such as congenital heart defects. Understanding GATA-5 function and regulation can provide insights into heart development and associated diseases, making anti-GATA-5 antibody (D-5) a valuable tool for researchers studying cardiovascular biology and related fields.

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GATA-5 Antibody (D-5) References:

1. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.  |  Dorfman, DM., et al. 1992. J Biol Chem. 267: 1279-85. PMID: 1370462
2. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.  |  Akiyama, Y., et al. 2003. Mol Cell Biol. 23: 8429-39. PMID: 14612389
3. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha.  |  Divine, JK., et al. 2004. Am J Physiol Gastrointest Liver Physiol. 287: G1086-99. PMID: 14715527
4. Transcription factor GATA-5 selectively up-regulates mucin gene expression.  |  Ren, CY., et al. 2004. J Cancer Res Clin Oncol. 130: 245-52. PMID: 14986113
5. The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.  |  Ritz-Laser, B., et al. 2005. Mol Endocrinol. 19: 759-70. PMID: 15539431
6. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.  |  Ko, LJ., et al. 1991. Mol Cell Biol. 11: 2778-84. PMID: 2017177
7. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.  |  Laverriere, AC., et al. 1994. J Biol Chem. 269: 23177-84. PMID: 8083222
8. DNA-binding specificities of the GATA transcription factor family.  |  Ko, LJ. and Engel, JD. 1993. Mol Cell Biol. 13: 4011-22. PMID: 8321208
9. The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.  |  Suzuki, E., et al. 1996. Genomics. 38: 283-90. PMID: 8975704

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GATA-5 Antibody (D-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GATA-5 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GATA-5 Antibody (D-5) Specifications

Alternate Product Name: GATA5

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 369-397

Epitope Target: GATA-5

Epitope Species: mouse

Product Reactivity/Detection: GATA-5

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GATA-5 Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent