GAS41 Antibody (YEATB1A8): sc-81278
- GAS41 Antibody (YEATB1A8) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of GAS41 of human origin
- recommended for detection of GAS41 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GAS41 Antibody (YEATB1A8). This work is in progress.
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GAS41 Antibody (YEATB1A8) is a mouse monoclonal IgG1 antibody that detects GAS41 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. GAS41, or glioma amplified sequence 41, is an evolutionarily conserved eukaryotic protein that plays a crucial role in cellular processes, particularly in tumor biology. GAS41 is primarily located in the nucleoli of neuroblastoma cells, which is significant because the nucleolus is essential for ribosome biogenesis and cellular stress responses. GAS41′s presence in the nucleoli suggests involvement in regulating these critical functions, especially in cancer, where ribosome production can be dysregulated. Additionally, GAS41 interacts with key proteins such as the MLL fusion partner AF10 and INI1, both of which are implicated in chromosomal translocations associated with hematologic malignancies. GAS41 is mapped to human chromosome 12q15, and expression is notably highest in the human brain, highlighting potential importance in neurodevelopmental processes and glioma progression. With unique localization and interaction profile, GAS41 serves as a valuable target for research into tumorigenesis and the molecular mechanisms underlying various cancers.
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GAS41 Antibody (YEATB1A8) References:
- GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. | Ding, X., et al. 2006. Nucleic Acids Res. 34: 2570-8. PMID: 16698963
- GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. | Park, JH. and Roeder, RG. 2006. Mol Cell Biol. 26: 4006-16. PMID: 16705155
- The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability. | Park, JH., et al. 2011. J Biol Chem. 286: 10911-7. PMID: 21317290
- Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. | Hsu, CC., et al. 2018. Cell Discov. 4: 28. PMID: 29900004
- GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. | Cho, HJ., et al. 2018. ACS Chem Biol. 13: 2739-2746. PMID: 30071723
- Development of potent dimeric inhibitors of GAS41 YEATS domain. | Listunov, D., et al. 2021. Cell Chem Biol. 28: 1716-1727.e6. PMID: 34289376
- GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. | Han, S., et al. 2022. Cell Oncol (Dordr). 45: 429-446. PMID: 35503594
- Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. | Liu, N., et al. 2023. Mol Cell. 83: 2206-2221.e11. PMID: 37311463
- Unveiling the role of GAS41 in cancer progression. | Ji, K., et al. 2023. Cancer Cell Int. 23: 245. PMID: 37853482
- GAS41 modulates ferroptosis by anchoring NRF2 on chromatin. | Wang, Z., et al. 2024. Nat Commun. 15: 2531. PMID: 38514704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GAS41 Antibody (YEATB1A8) | sc-81278 | 100 µg/ml | $339.00 |