GAP1-InsP₄ BP Antibody (H-6): sc-374555

GAP1-InsP4 BP Antibody (H-6) is a mouse monoclonal IgG1 antibody that detects GAP1-InsP4 BP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GAP1-InsP4 BP, also known as Ras p21 protein activator (GTPase-activating protein) 3, is an 829-amino acid protein that plays a crucial role in cellular signaling by binding phospholipids in both calcium-dependent and -independent manners. GAP1-InsP4 BP (H-6) antibody targets a member of the Ras GTPase-activating protein family, which includes four distinct genes: GAP1(m), GAP1-InsP4 BP, MRASAL, and KIAA0538. The structure of GAP1-InsP4 BP is characterized by an N-terminal tandem C2 domain, a GAP-related domain, and a C-terminal pleckstrin homology (PH) domain, with the PH domain being particularly important for membrane targeting as GAP1-InsP4 BP binds specific phospholipids. Following the stimulation of phosphatidylinositol 3,4,5-trisphosphate production, GAP1-InsP4 BP selectively interacts with inositol phosphates, facilitating their localization to the plasma membrane, which is vital for the regulation of various signaling pathways. GAP1-InsP4 BP (H-6) monoclonal antibody serves as an essential tool for researchers studying the intricate mechanisms of cellular signaling and the role of inositol phosphates in health and disease.

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GAP1-InsP₄ BP Antibody (H-6) References:

1. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.  |  Fang, J., et al. 2017. Nat Immunol. 18: 236-245. PMID: 28024152
2. Implicating candidate genes at GWAS signals by leveraging topologically associating domains.  |  Way, GP., et al. 2017. Eur J Hum Genet. 25: 1286-1289. PMID: 28792001
3. Rho GTPase‑activating protein 1 promotes apoptosis of myocardial cells in an ischemic cardiomyopathy model.  |  Zhang, X., et al. 2019. Kardiol Pol. 77: 1163-1169. PMID: 31664016
4. MiR-34b-5p inhibits cell proliferation, migration and invasion through targeting ARHGAP1 in breast cancer.  |  Dong, L., et al. 2020. Am J Transl Res. 12: 269-280. PMID: 32051752
5. Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1.  |  Liang, M., et al. 2021. Mol Ther Nucleic Acids. 23: 1191-1203. PMID: 33664997
6. Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.  |  Chichili, VPR., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34006635
7. Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis from the SORAMIC Trial.  |  Shuen, TWH., et al. 2022. Clin Cancer Res. 28: 3890-3901. PMID: 35763041
8. Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease.  |  Shen, N., et al. 2023. Ann Transl Med. 11: 173. PMID: 36923095
9. Rho GTPase-activating protein 1 promotes hepatocellular carcinoma progression via modulation by CircPIP5K1A/MiR-101-3p.  |  Xu, Y., et al. 2024. Hepatol Res. 54: 174-188. PMID: 37792600
10. CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells.  |  Zhou, S., et al. 2024. Cell Rep Med. 5: 101844. PMID: 39637858

The preferred GAP1-InsP₄ BP antibody is GAP1-InsP₄ BP Antibody (E-9): sc-398283.