γ1-Adaptin Antibody (100/3): sc-58214
- γ1-Adaptin Antibody (100/3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against full length γ1-Adaptin of bovine origin
- recommended for detection of γ1-Adaptin 100 kDa in bovine liver, human heart fibroblasts and Madin-Darby bovine kidney cultured cells (MDBK) of bovine and human origin by WB, IP and ELISA; non cross-reactive with any components in the 110-115 kDa range from above mentioned sources, rat pheochromocytoma cultured cells (PC12), neuroblastoma or astrocytes, or with the γ-subunit in rat and mouse
- m-IgG2b BP-HRP is the preferred secondary detection reagent for γ1-Adaptin Antibody (100/3) for WB applications. This reagent is now offered in a bundle with γ1-Adaptin Antibody (100/3) (see ordering information below).
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γ1-Adaptin Antibody (100/3) is a mouse monoclonal IgG2b antibody that detects γ1-Adaptin in bovine and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). γ1-Adaptin plays a crucial role in the clathrin-mediated endocytosis process, which is essential for the internalization of receptors and other membrane proteins, thereby regulating various cellular functions including nutrient uptake and signal transduction. γ1-Adaptin is primarily located at the cytoplasmic side of the plasma membrane, where γ1-Adaptin interacts with clathrin and other adaptor proteins to facilitate the formation of clathrin-coated pits and vesicles. Proper functioning of γ1-Adaptin is vital for maintaining cellular homeostasis and ensuring efficient communication between cells, as disruptions in this process can lead to various diseases, including cancer and neurodegenerative disorders. γ1-Adaptin also exhibits post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring γ1-Adaptin′s importance in cellular dynamics. anti-γ1-Adaptin antibody (100/3) is an invaluable tool for researchers studying endocytic pathways and their implications in health and disease.
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γ1-Adaptin Antibody (100/3) References:
- Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. | Deneka, M., et al. 2003. EMBO J. 22: 2645-57. PMID: 12773381
- CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking. | Tavares, LA., et al. 2017. J Cell Sci. 130: 429-443. PMID: 27909244
- De novo and bi-allelic variants in AP1G1 cause neurodevelopmental disorder with developmental delay, intellectual disability, and epilepsy. | Usmani, MA., et al. 2021. Am J Hum Genet. 108: 1330-1341. PMID: 34102099
- Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. | Rebendenne, A., et al. 2022. Nat Genet. 54: 1090-1102. PMID: 35879413
- Identification of methylation-driven genes, circulating miRNAs and their potential regulatory mechanisms in gestational diabetes mellitus. | Ju, Y., et al. 2023. Am J Transl Res. 15: 336-349. PMID: 36777869
- Usmani-Riazuddin syndrome can have a recognizable phenotype: Report of a novel AP1G1 variant. | Gnazzo, M., et al. 2024. Clin Genet. 106: 109-113. PMID: 38665048
- Whole genome sequencing for copy number variant detection to improve diagnosis and management of rare diseases. | Bowman, P., et al. 2025. Dev Med Child Neurol. 67: 126-131. PMID: 38840441
- Identification of a Novel hsa_circ_0058058/miR-324-5p Axis and Prognostic/Predictive Molecules for Acute Myeloid Leukemia Outcome by Bioinformatics-Based Analysis. | Misir, S., et al. 2024. Biology (Basel). 13: PMID: 39056681
- OTUD1 regulates cytokine expression and related pathways in goose fatty liver by promoting deubiquitination of its target proteins. | Zhou, X., et al. 2024. Poult Sci. 103: 104382. PMID: 39437555
- The clathrin adaptor AP1-S1 is associated with immune infiltration and HLA loss, as a potential therapeutic target in lung adenocarcinoma. | Liu, Y., et al. 2025. Int Immunopharmacol. 152: 114385. PMID: 40049084
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ1-Adaptin Antibody (100/3) | sc-58214 | 200 µg/ml | $316.00 | |||
γ1-Adaptin Antibody (100/3): m-IgG2b BP-HRP Bundle | sc-548439 | 200 µg Ab; 10 µg BP | $354.00 |