γ-parvin Antibody (F-9): sc-271380

γ-parvin Antibody (F-9) is a mouse monoclonal IgG2b antibody that detects γ-parvin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-parvin is a crucial member of the parvin family, which includes α-parvin and β-parvin, and plays a significant role in linking integrins and associated proteins to intracellular signaling pathways that regulate actin cytoskeletal dynamics and cell survival. γ-parvin is predominantly localized to focal adhesions, where γ-parvin facilitates cell adhesion, spreading, motility, and survival by interacting with key partners such as integrin-linked kinase (ILK), paxillin, α-actinin, and testicular kinase 1. Notably, γ-parvin is essential for establishing cell polarity, which is critical for leukocyte migration, thereby influencing immune responses. The complex formed by γ-parvin and ILK is particularly important for maintaining cell integrity in various cell types, including cancer cells, kidney podocytes, and cardiac myocytes. γ-parvin expression is widespread, with significant levels found in skeletal muscle, heart, liver, and kidney, underscoring γ-parvin′s importance in both normal physiology and pathological conditions. With an ability to modulate actin dynamics and cell signaling, γ-parvin is a vital target for research into cellular processes and disease mechanisms.

The preferred γ-parvin antibody is γ-parvin Antibody (G-8): sc-393593.