γ-parvin Antibody (D-6): sc-166294

γ-parvin Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects γ-parvin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-parvin is a crucial member of the parvin family, which includes α-parvin and β-parvin, and plays a significant role in linking integrins and associated proteins to intracellular signaling pathways that regulate actin cytoskeletal dynamics and cell survival. γ-parvin is predominantly localized to focal adhesions, where γ-parvin facilitates cell adhesion, spreading, motility, and survival by interacting with key partners such as integrin-linked kinase (ILK), paxillin, α-actinin, and testicular kinase 1. Notably, γ-parvin is essential for establishing cell polarity, which is critical for leukocyte migration, thereby influencing immune responses. The complex formed by ILK and γ-parvin is vital for maintaining cellular integrity and function, particularly in various cell types, including those involved in cancer progression and tissue repair. With broad expression across tissues, including skeletal muscle, heart, liver, and kidney, γ-parvin serves as a pivotal player in cellular processes, making anti-γ-parvin antibody (D-6) an invaluable tool for researchers studying cell adhesion and migration mechanisms.

The preferred γ-parvin antibody is γ-parvin Antibody (G-8): sc-393593.