γ-parvin Antibody (C-5): sc-390388
- γ-parvin Antibody (C-5) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against amino acids 1-141 mapping at the N-terminus of γ-parvin of human origin
- recommended for detection of γ-parvin of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for γ-parvin Antibody (C-5). This work is in progress.
γ-parvin Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects γ-parvin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-parvin is a crucial member of the parvin family, which plays a significant role in linking integrins and associated proteins to intracellular signaling pathways that regulate actin cytoskeletal dynamics and cell survival. γ-parvin is predominantly localized to focal adhesions, where γ-parvin facilitates essential cellular processes such as adhesion, spreading, motility, and survival by interacting with key partners like integrin-linked kinase (ILK), paxillin, α-actinin, and testicular kinase 1. Notably, γ-parvin is vital for establishing cell polarity, particularly in leukocyte migration, which is essential for immune responses. The interaction of γ-parvin with ILK and the LIM protein PINCH-1 forms a complex that is critical for cell survival across various cell types, including certain cancer cells, kidney podocytes, and cardiac myocytes. γ-parvin expression is widespread, with particularly high levels found in skeletal muscle, heart, liver, and kidney, underscoring γ-parvin′s importance in maintaining cellular integrity and function. With γ-parvin′s ability to facilitate rapid actin reorganization and support cell migration, anti-γ-parvin antibody (C-5) is an invaluable tool for researchers studying cellular dynamics and signaling pathways in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-parvin Antibody (C-5) | sc-390388 | 200 µg/ml | $322.00 |