γ Enolase Antibody (NSE-P1): sc-21738

γ Enolase Antibody (NSE-P1) is a mouse monoclonal IgG1 kappa light chain antibody that detects gamma Enolase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). γ Enolase Antibody (NSE-P1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gamma Enolase protein, also known as ENO2, plays a crucial role in the glycolytic pathway, specifically in the conversion of 2-phosphoglycerate to phosphoenolpyruvate, which is a key step in energy production. ENO2 is predominantly expressed in the nervous system, making gamma Enolase (NSE-P1) antibody an important marker for neuronal differentiation and function. Gamma Enolase presence in neural tissues, as opposed to α Enolase and β Enolase isoforms found in various tissues and muscle respectively, highlights ENO2′s significance in neurological studies and potential implications in neurodegenerative diseases. Gamma Enolase (NSE-P1) antibody expression and regulation studies can provide insights into neuronal health and metabolic processes that underlie brain function.

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γ Enolase Antibody (NSE-P1) References:

1. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients.  |  Maruyama, I., et al. 2000. Invest Ophthalmol Vis Sci. 41: 1657-65. PMID: 10845582
2. Purification and characterization of gamma-enolase from various mammals.  |  Aoki, T., et al. 1992. Chem Pharm Bull (Tokyo). 40: 1236-9. PMID: 1394640
3. Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells.  |  Obermajer, N., et al. 2009. Int J Biochem Cell Biol. 41: 1685-96. PMID: 19433310
4. γ-1-syntrophin mediates trafficking of γ-enolase towards the plasma membrane and enhances its neurotrophic activity.  |  Hafner, A., et al. 2010. Neurosignals. 18: 246-58. PMID: 21358174
5. Ferulic acid prevents the injury-induced decrease of γ-enolase expression in brain tissue and HT22 cells.  |  Gim, SA. and Koh, PO. 2014. Lab Anim Res. 30: 8-13. PMID: 24707299
6. Neuron-specific gamma-enolase derived from human glioma.  |  Kuramitsu, M., et al. 1986. Neurochem Pathol. 4: 89-105. PMID: 3014401
7. Selective localization of gamma-enolase in stromal cells of cerebellar hemangioblastomas.  |  Feldenzer, JA. and McKeever, PE. 1987. Acta Neuropathol. 72: 281-5. PMID: 3105228
8. Immunohistochemical localization of gamma-enolase in early human embryos.  |  Shinohara, H., et al. 1986. Brain Res. 382: 33-8. PMID: 3768679
9. Human gamma gamma-enolase: two-site immunoradiometric assay with a single monoclonal antibody.  |  Soler-Federsppiel, BS., et al. 1987. J Neurochem. 48: 22-8. PMID: 3794703
10. Alpha gamma-enolase in the rat: ontogeny and tissue distribution.  |  Jørgensen, OS. and Centervall, G. 1982. J Neurochem. 39: 537-42. PMID: 7086434

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-γ Enolase Antibody (NSE-P1) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-γ Enolase Antibody (NSE-P1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

γ Enolase Antibody (NSE-P1) Specifications

Alternate Product Name: γ Enolase

Product Clone Name: NSE-P1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 416-433

Epitope Target: γ Enolase

Epitope Species: human

Product Reactivity/Detection: γ Enolase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for γ Enolase Antibody (NSE-P1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred γ Enolase antibody is γ Enolase Antibody (D-7): sc-376375.