γ-catenin Antibody (H-1): sc-8415
- γ-catenin Antibody (H-1) is a mouse monoclonal IgG1 κ, cited in 18 publications, provided at 200 µg/ml
- raised against amino acids 30-109 mapping near the N-terminus of γ-catenin of human origin
- recommended for detection of γ-catenin of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for γ-catenin Antibody (H-1) for WB and IHC(P) applications. These reagents are now offered in bundles with γ-catenin Antibody (H-1) (see ordering information below).
QUICK LINKS
SEE ALSO...
γ-catenin Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects γ-catenin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). γ-catenin, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, such as E-cadherin and N-cadherin, which are essential for maintaining tissue integrity and structure. γ-catenin is primarily located in the cytoplasm and at the cell membrane, where γ-catenin interacts with the cytoplasmic tail of cadherins, facilitating the connection between the cytoskeleton and cell adhesion molecules. This localization ensures that cells can effectively communicate and adhere to one another, which is critical for processes such as tissue development and repair. Additionally, γ-catenin is involved in signaling pathways that regulate cell proliferation and differentiation, making γ-catenin an important player in both normal physiology and disease states, including cancer. Anti-γ-catenin antibody (H-1) is an invaluable tool for researchers studying the dynamics of cell adhesion and the molecular mechanisms underlying various cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
γ-catenin Antibody (H-1) References:
- The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells. | Kim, YM., et al. 2011. Curr Cancer Drug Targets. 11: 213-25. PMID: 21158719
- Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer. | Fang, WK., et al. 2014. World J Gastroenterol. 20: 5839-48. PMID: 24914344
- The clinical significance of γ-catenin in acute myeloid leukemia. | Xu, J., et al. 2016. Onco Targets Ther. 9: 3861-71. PMID: 27390526
- γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer. | Nagel, JM., et al. 2017. Int J Colorectal Dis. 32: 1243-1251. PMID: 28681073
- γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia. | Luong-Gardiol, N., et al. 2019. Cancer Cell. 35: 649-663.e10. PMID: 30991025
- γ-catenin alleviates cardiac fibrosis through inhibiting phosphorylation of GSK-3β. | Tang, X., et al. 2019. J Biomed Res. 0: 1-9. PMID: 31741464
- β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. | Zhao, X., et al. 2020. Elife. 9: PMID: 32820720
- miR-195-5p as Regulator of γ-Catenin and Desmosome Junctions in Colorectal Cancer. | Piccinno, E., et al. 2023. Int J Mol Sci. 24: PMID: 38069408
- Downregulation of γ-Catenin by miR-195-5p Inhibits Colon Cancer Progression, Regulating Desmosome Function. | Piccinno, E., et al. 2023. Int J Mol Sci. 25: PMID: 38203664
- Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). | Obama, H. and Ozawa, M. 1997. J Biol Chem. 272: 11017-20. PMID: 9110993
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-catenin Antibody (H-1) | sc-8415 | 200 µg/ml | $316.00 | |||
γ-catenin Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-538893 | 200 µg Ab; 10 µg BP | $354.00 | |||
γ-catenin Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-541128 | 200 µg Ab; 20 µg BP | $354.00 |