γ-Actin Antibody (2-4): sc-65634
- γ-Actin Antibody (2-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised aginast cytoplasmic γ-Actin from brain tissue of bovine origin
- recommended for detection of γ Actin of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including bovine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for γ-Actin Antibody (2-4) for WB applications. This reagent is now offered in a bundle with γ-Actin Antibody (2-4) (see ordering information below).
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γ-Actin Antibody (2-4) is a mouse monoclonal IgG1 antibody that detects γ-Actin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). γ-Actin is a crucial component of the cytoskeleton, playing a vital role in maintaining cell shape, enabling cellular motility, and facilitating intracellular transport. γ-Actin is predominantly found in non-muscle cells, where anti-γ-Actin antibody (2-4) can detect its contribution to the formation of the actin filament network, essential for various cellular processes, including cell division and signal transduction. γ-Actin′s presence in the cytoplasm allows for dynamic remodeling of the cytoskeleton in response to external stimuli, which is critical for processes such as wound healing and immune responses. γ-Actin interacts with a variety of proteins, including myosin, which is essential for muscle contraction and cellular movement, highlighting γ-Actin′s importance in both structural integrity and functional dynamics of cells. γ-Actin monoclonal antibody (2-4) serves as an invaluable tool for researchers studying the intricate roles of actin in cellular functions and its implications in various diseases.
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γ-Actin Antibody (2-4) References:
- Gamma-actin is required for cytoskeletal maintenance but not development. | Belyantseva, IA., et al. 2009. Proc Natl Acad Sci U S A. 106: 9703-8. PMID: 19497859
- Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers. | Gokhin, DS. and Fowler, VM. 2011. J Cell Biol. 194: 105-20. PMID: 21727195
- γ-Actin plays a key role in endothelial cell motility and neovessel maintenance. | Pasquier, E., et al. 2015. Vasc Cell. 7: 2. PMID: 25705373
- Evidence for changes in beta- and gamma-actin proportions during inner ear hair cell life. | Andrade, LR. 2015. Cytoskeleton (Hoboken). 72: 282-91. PMID: 26033950
- Divergent roles of β- and γ-actin isoforms during spread of vaccinia virus. | Marzook, NB., et al. 2017. Cytoskeleton (Hoboken). 74: 170-183. PMID: 28218453
- YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization. | Wu, N., et al. 2021. Mol Ther. 29: 1138-1150. PMID: 33279723
- Different translation dynamics of β- and γ-actin regulates cell migration. | Vedula, P., et al. 2021. Elife. 10: PMID: 34165080
- Cytoplasmic Beta and Gamma Actin Isoforms Reorganization and Regulation in Tumor Cells in Culture and Tissue. | Dugina, VB., et al. 2022. Front Pharmacol. 13: 895703. PMID: 35721191
- SUMOylation of Nuclear γ-Actin by SUMO2 supports DNA Damage Repair against Myocardial Ischemia-Reperfusion Injury. | Zhao, W., et al. 2022. Int J Biol Sci. 18: 4595-4609. PMID: 35864967
- Differential N-terminal processing of beta and gamma actin. | Chen, L., et al. 2022. iScience. 25: 105186. PMID: 36248738
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-Actin Antibody (2-4) | sc-65634 | 200 µg/ml | $322.00 | |||
γ-Actin Antibody (2-4): m-IgG Fc BP-HRP Bundle | sc-539188 | 200 µg Ab; 10 µg BP | $361.00 |