G_{α t1} Antibody (C-9): sc-518139

Gα t1 Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects Gα t1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Gα t1 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gα t1, also called GNAT1, is a crucial component of the heterotrimeric G protein signaling pathway, which plays a vital role in transmitting signals from cell surface receptors to intracellular effectors. Specifically, Gα t1 is involved in the visual signaling cascade, where Gα t1 interacts with photorhodopsin in rod cells, facilitating the exchange of guanine nucleotides. This exchange is essential for the conversion of light signals into electrical signals in the retina, ultimately contributing to vision. Proper functioning of Gα t1 is critical for phototransduction, and any dysfunction can lead to visual impairments or disorders. With an ability to bind and hydrolyze GTP, Gα t1 regulates the activity of downstream effectors, making Gα t1 a key player in the intricate network of cellular signaling.

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G_{α t1} Antibody (C-9) References:

1. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
2. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
3. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
4. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
5. GNAT1 associated with autosomal recessive congenital stationary night blindness.  |  Naeem, MA., et al. 2012. Invest Ophthalmol Vis Sci. 53: 1353-61. PMID: 22190596
6. A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.  |  Carrigan, M., et al. 2016. Br J Ophthalmol. 100: 495-500. PMID: 26472407
7. A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit.  |  Ye, C., et al. 2016. J Exp Clin Cancer Res. 35: 187. PMID: 27912775
8. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.  |  Jones, DT. and Reed, RR. 1987. J Biol Chem. 262: 14241-9. PMID: 2820999
9. Coexistence of GNAT1 and ABCA4 variants associated with Nougaret-type congenital stationary night blindness and childhood-onset cone-rod dystrophy.  |  Hayashi, T., et al. 2020. Doc Ophthalmol. 140: 147-157. PMID: 31583501
10. Long Non-coding RNA lnc-GNAT1-1 Suppresses Liver Cancer Progression via Modulation of Epithelial-Mesenchymal Transition.  |  Wang, J., et al. 2020. Front Genet. 11: 1029. PMID: 33193591
11. The Plastidial Protein Acetyltransferase GNAT1 Forms a Complex With GNAT2, yet Their Interaction Is Dispensable for State Transitions.  |  Brünje, A., et al. 2024. Mol Cell Proteomics. 23: 100850. PMID: 39349166
12. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_{α t1} Antibody (C-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-G_{α t1} Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_{α t1} Antibody (C-9) Specifications

Alternate Product Name: Gα t1

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 124-144

Epitope Target: G_{α t1}

Epitope Species: mouse

Product Reactivity/Detection: G_{α t1}

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for G_{α t1} Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin