Gα s/olf Antibody (C-10): sc-377435
- Gα s/olf Antibody (C-10) is a mouse monoclonal IgG2a κ Gα s/olf antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 369-394 at the C-terminus of Gα s of rat origin
- recommended for detection of Gα s and Gα olf of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- See Gα s/olf (A-5): sc-55545 for Gα s/olf antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Gα s/olf Antibody (C-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Gα s/olf Antibody (C-10) (see ordering information below).
Gα s/olf Antibody (C-10) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect the Gαs and Gαolf proteins across multiple species, including mouse, rat, human, canine, bovine, porcine, and avian, through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Gα s/olf (C-10) antibody targets a precise epitope located between amino acids 369-394 at the C-terminus of the rat Gαs protein, ensuring selective binding to the Gαs/olf subunits. Gαs, also known as GNAS or G-protein subunit alpha S, and Gαolf, referred to as GNAL or G-protein subunit alpha L, are integral components of heterotrimeric G proteins that play a crucial role in transmitting extracellular signals from a variety of receptors, including hormone and neurotransmitter receptors, to intracellular effectors like adenylate cyclase. These proteins interact with βγ subunits, which are essential for regulating downstream signaling pathways, and with regulators of G protein signaling (RGS) proteins that modulate the activity and duration of the G protein signal by enhancing GTPase activity. Additionally, Gαs/olf proteins engage with specific receptors such as β-adrenergic and olfactory receptors, facilitating the activation of adenylate cyclase and the subsequent production of cyclic AMP, a key second messenger in cellular signaling. By targeting these interactions, anti-Gα s/olf antibody (C-10) serves as a powerful tool for researchers investigating G protein-coupled receptor signaling mechanisms in various biological systems. Available in a non-conjugated form, Gα s/olf monoclonal antibody (C-10) provides reliable and precise detection of Gαs and Gαolf proteins, making this reagent essential for studies focused on signal transduction, receptor function, and cellular communication.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gα s/olf Antibody (C-10) | sc-377435 | 200 µg/ml | $316.00 | |||
Gα s/olf Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-538045 | 200 µg Ab; 10 µg BP | $354.00 | |||
Gα s/olf Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-535569 | 200 µg Ab; 40 µg BP | $354.00 | |||
Gα s/olf Antibody (C-10): m-IgG2a BP-HRP Bundle | sc-548186 | 200 µg Ab; 10 µg BP | $354.00 | |||
Gα s/olf (C-10) Neutralizing Peptide | sc-377435 P | 100 µg/0.5 ml | $68.00 |