G_{α 13} Antibody (6F6-B5): sc-293424

Gα 13 Antibody (6F6-B5) is a mouse monoclonal IgG1 kappa light chain antibody that detects G alpha 13 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-G alpha 13 antibody (6F6-B5) is available as the non-conjugated format. G alpha 13 protein plays a crucial role in cellular signaling pathways by acting as a molecular switch that transmits signals from activated G protein-coupled receptors to downstream effectors, such as RhoGEFs, which in turn activate the Rho family of small GTPases. This signaling is vital for various physiological processes, including cell proliferation, migration, and cytoskeletal organization. G alpha 13′s interaction with specific RhoGEFs highlights its importance in regulating the actin cytoskeleton and influencing cellular responses to external stimuli. Given its significant role in mediating cellular responses, G alpha 13 is of great interest in the study of various diseases, including cancer and cardiovascular disorders, where aberrant signaling can lead to pathological conditions. With broad species reactivity and proven applications, G alpha 13 monoclonal antibody (6F6-B5) is an essential tool for researchers investigating the intricate signaling mechanisms involving G proteins.

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G_{α 13} Antibody (6F6-B5) References:

1. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
2. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
3. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
4. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
5. G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.  |  Strathmann, MP. and Simon, MI. 1991. Proc Natl Acad Sci U S A. 88: 5582-6. PMID: 1905812
6. Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.  |  Strathmann, M., et al. 1989. Proc Natl Acad Sci U S A. 86: 7407-9. PMID: 2508088
7. G-Protein Gα13 Functions with Abl Kinase to Regulate Actin Cytoskeletal Reorganization.  |  Wang, L., et al. 2017. J Mol Biol. 429: 3836-3849. PMID: 29079481
8. Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer.  |  Yagi, H., et al. 2019. FASEB J. 33: 13683-13694. PMID: 31569999
9. Gα12/13 signaling in metabolic diseases.  |  Yang, YM., et al. 2020. Exp Mol Med. 52: 896-910. PMID: 32576930
10. Gα12 and Gα13: Versatility in Physiology and Pathology.  |  Guo, P., et al. 2022. Front Cell Dev Biol. 10: 809425. PMID: 35237598
11. Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity.  |  Redlin, F., et al. 2022. Commun Biol. 5: 1287. PMID: 36434027
12. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_{α 13} Antibody (6F6-B5) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-G_{α 13} Antibody (6F6-B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_{α 13} Antibody (6F6-B5) Specifications

Alternate Product Name: G protein subunit GNA13

Product Clone Name: 6F6-B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-377

Epitope Target: G_{α 13}

Epitope Species: human

Product Reactivity/Detection: Gα 13

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for G_{α 13} Antibody (6F6-B5): N/A

The preferred G_{α 13} antibody is G_{α 13} Antibody (A-6): sc-518113.