galectin-7 Antibody (G-3): sc-137085
- galectin-7 Antibody (G-3) is a mouse monoclonal IgG1 κ galectin-7 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 77-136 mapping at the C-terminus of galectin-7 of human origin
- galectin-7 Antibody (G-3) is recommended for detection of galectin-7 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-galectin-7 Antibody (G-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for galectin-7 Antibody (G-3) for WB and IHC(P) applications. These reagents are now offered in bundles with galectin-7 Antibody (G-3) (see ordering information below).
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Galectin-7 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects galectin-7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-galectin-7 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Galectin-7, also known as LGALS7, plays a crucial role in cellular processes, particularly in regulating apoptosis, which is vital for maintaining tissue homeostasis and preventing tumorigenesis. Galectin-7 is predominantly expressed in stratified squamous epithelium and is activated by p53 while being repressed by retinoic acid. Galectin-7′s pro-apoptotic function is mediated through c-Jun N-terminal kinase (JNK) activation and cytochrome c release, highlighting galectin-7′s importance in the intrinsic pathway of apoptosis. LGALS7 is located on chromosome 19, and LGALS7′s interactions with other proteins can influence cell survival and death, making galectin-7 a significant target for research in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
galectin-7 Antibody (G-3) References:
- Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. | Bernerd, F., et al. 1999. Proc Natl Acad Sci U S A. 96: 11329-34. PMID: 10500176
- Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. | Kuwabara, I., et al. 2002. J Biol Chem. 277: 3487-97. PMID: 11706006
- Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. | Cao, Z., et al. 2002. J Biol Chem. 277: 42299-305. PMID: 12194966
- Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications. | Rorive, S., et al. 2002. Mod Pathol. 15: 1294-301. PMID: 12481010
- Galectin-7 as a potential mediator of corneal epithelial cell migration. | Cao, Z., et al. 2003. Arch Ophthalmol. 121: 82-6. PMID: 12523890
- Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype. | Moisan, S., et al. 2003. Leukemia. 17: 751-9. PMID: 12682633
- Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin. | Hirabayashi, J., et al. 1989. Biochim Biophys Acta. 1008: 85-91. PMID: 2719964
- Molecular cloning, characterization, and expression of a human 14-kDa lectin. | Couraud, PO., et al. 1989. J Biol Chem. 264: 1310-6. PMID: 2910856
- Cloning, expression, and chromosome mapping of human galectin-7. | Madsen, P., et al. 1995. J Biol Chem. 270: 5823-9. PMID: 7534301
- Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. | Magnaldo, T., et al. 1995. Dev Biol. 168: 259-71. PMID: 7729568
- Galectin-7, a marker of all types of stratified epithelia. | Magnaldo, T., et al. 1998. Differentiation. 63: 159-68. PMID: 9697310
- Structural basis for the recognition of carbohydrates by human galectin-7. | Leonidas, DD., et al. 1998. Biochemistry. 37: 13930-40. PMID: 9760227
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-7 Antibody (G-3) | sc-137085 | 200 µg/ml | $316.00 | |||
galectin-7 Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-528857 | 200 µg Ab; 10 µg BP | $354.00 | |||
galectin-7 Antibody (G-3): m-IgGκ BP-HRP Bundle | sc-521422 | 200 µg Ab, 40 µg BP | $354.00 | |||
galectin-7 Antibody (G-3): m-IgG1 BP-HRP Bundle | sc-543171 | 200 µg Ab; 20 µg BP | $354.00 | |||
galectin-7 Antibody (G-3) AC | sc-137085 AC | 500 µg/ml, 25% agarose | $416.00 | |||
galectin-7 Antibody (G-3) HRP | sc-137085 HRP | 200 µg/ml | $316.00 | |||
galectin-7 Antibody (G-3) FITC | sc-137085 FITC | 200 µg/ml | $330.00 | |||
galectin-7 Antibody (G-3) PE | sc-137085 PE | 200 µg/ml | $343.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 488 | sc-137085 AF488 | 200 µg/ml | $357.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 546 | sc-137085 AF546 | 200 µg/ml | $357.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 594 | sc-137085 AF594 | 200 µg/ml | $357.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 647 | sc-137085 AF647 | 200 µg/ml | $357.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 680 | sc-137085 AF680 | 200 µg/ml | $357.00 | |||
galectin-7 Antibody (G-3) Alexa Fluor® 790 | sc-137085 AF790 | 200 µg/ml | $357.00 |