galectin-4 Antibody (F-1): sc-376603

galectin-4 Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects Galectin-4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Galectin-4, also known as Gal-4, L36, or LGALS4, is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in various biological processes, including cell adhesion, tumor progression, and apoptosis. Galectin-4 is composed of 323 amino acids and features two homologous carbohydrate recognition domains, which are essential for binding activity and functional versatility. Notably, Galectin-4 is primarily expressed in epithelial cells of the colon, rectum, and intestine, and expression levels are closely associated with the malignant potential of human hepatocellular carcinoma. Galectin-4 expression is influenced by factors such as cell-cell contact, serum growth factors, and the differentiation status of cells, making anti-Galectin-4 antibody (F-1) a significant marker in cancer research. Notably, Galectin-4 is underexpressed in colorectal cancer, yet preferentially upregulated in cells prone to peritoneal dissemination, highlighting Galectin-4′s potential as a therapeutic target and biomarker for disease progression.

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galectin-4 Antibody (F-1) References:

1. Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.  |  Delacour, D., et al. 2005. J Cell Biol. 169: 491-501. PMID: 15883199
2. Galectin-4 expression in carcinoid tumors.  |  Rumilla, KM., et al. 2006. Endocr Pathol. 17: 243-9. PMID: 17308361
3. Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function.  |  Fernández-Calotti, P., et al. 2016. FASEB J. 30: 544-54. PMID: 26481311
4. Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose.  |  Bum-Erdene, K., et al. 2016. Sci Rep. 6: 20289. PMID: 26828567
5. Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication.  |  Rustiguel, JK., et al. 2016. Sci Rep. 6: 33633. PMID: 27642006
6. Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines.  |  Rao, US. and Rao, PS. 2017. Tumour Biol. 39: 1010428317691687. PMID: 28345468
7. Galectin-4 Is Involved in the Structural Changes of Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer Cells with High Metastatic Potential.  |  Hachisu, K., et al. 2023. Int J Mol Sci. 24: PMID: 37569679
8. Exploring galectin interactions with human milk oligosaccharides and blood group antigens identifies BGA6 as a functional galectin-4 ligand.  |  Cagnoni, AJ., et al. 2024. J Biol Chem. 300: 107573. PMID: 39009340
9. High expression of B3GALT5 suppresses the galectin-4-mediated peritoneal dissemination of poorly differentiated gastric cancer cells.  |  Tsuchida, A., et al. 2024. Glycobiology. 34: PMID: 39163480
10. Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.  |  Huflejt, ME., et al. 1997. J Biol Chem. 272: 14294-303. PMID: 9162064

The preferred galectin-4 antibody is galectin-4 Antibody (E-2): sc-271209.