GAD-67 Antibody (A-4): sc-390383
- GAD-67 Antibody (A-4) is a mouse monoclonal IgG3 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 4-31 at the N-terminus of GAD-67 of human origin
- recommended for detection of GAD-67 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- See GAD-67 (F-6): sc-28376 for GAD-67 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for GAD-67 Antibody (A-4) for WB applications. This reagent is now offered in a bundle with GAD-67 Antibody (A-4) (see ordering information below).
GAD-67 Antibody (A-4) is a mouse monoclonal IgG3 antibody that detects glutamic acid decarboxylase 67 (GAD-67) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GAD-67 plays a crucial role in the synthesis of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system, which is essential for maintaining the balance between neuronal excitation and inhibition. This balance is vital for normal brain function, as disruptions can lead to various neurological disorders, including epilepsy and anxiety. GAD-67 is predominantly localized in the cytoplasm of neurons, where GAD-67 is responsible for the basal production of GABA, ensuring that adequate levels are maintained for neurotransmission. In contrast, GAD-65, which is activated during periods of increased GABA demand, is found in synaptic vesicle membranes, highlighting the complementary roles of these two isoforms in GABAergic signaling. Anti-GAD-67 antibody (A-4) is an invaluable tool for researchers studying GABA synthesis and its implications in neurobiology, providing insights into the mechanisms underlying various neurological conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GAD-67 Antibody (A-4) | sc-390383 | 200 µg/ml | $316.00 | |||
GAD-67 Antibody (A-4): m-IgG3 BP-HRP Bundle | sc-550478 | 200 µg Ab; 40 µg BP | $354.00 | |||
GAD-67 (A-4) Neutralizing Peptide | sc-390383 P | 100 µg/0.5 ml | $68.00 |