Date published: 2026-4-26

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GAD Inhibitors

Santa Cruz Biotechnology now offers a broad range of GAD Inhibitors for use in various applications. Glutamate decarboxylase (GAD) is an enzyme critical for the conversion of glutamate, the primary excitatory neurotransmitter, into gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the central nervous system. GAD Inhibitors are essential tools in scientific research, enabling the exploration of how GABA production is regulated and how the balance between excitatory and inhibitory signals in the brain is maintained. By inhibiting GAD activity, researchers can study the impact on GABA levels, neural excitability, and synaptic transmission, providing insights into the mechanisms that underlie various physiological processes such as neural circuit modulation, synaptic plasticity, and behavior. These inhibitors are widely utilized in neurobiological studies, electrophysiological research, and behavioral experiments to understand how altered GABAergic signaling affects brain function and contributes to neurological conditions. GAD Inhibitors are particularly valuable in studies focusing on the role of GABA in neurodevelopment, learning, and memory, as well as in investigations into the dysregulation of GABA synthesis in disorders such as epilepsy, anxiety, and schizophrenia. The availability of these inhibitors has significantly advanced research in neuroscience and molecular biology, offering critical tools for dissecting the complex interactions between excitatory and inhibitory neurotransmission. View detailed information on our available GAD Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Allylglycine

16338-48-0sc-255236
sc-255236A
sc-255236B
sc-255236C
sc-255236D
1 g
5 g
10 g
25 g
100 g
$73.00
$245.00
$401.00
$785.00
$2071.00
3
(1)

L-Allylglycine acts as a selective inhibitor of the enzyme GABA transaminase, showcasing unique molecular interactions that disrupt the enzymatic pathway of GABA metabolism. Its structural features facilitate specific binding to the active site, leading to altered reaction kinetics and a notable increase in GABA levels. The compound's polar characteristics enhance its solubility in aqueous environments, influencing its bioavailability and interaction with cellular components.