GABP-β1/2 Antibody (11): sc-130315

GABP-β1/2 Antibody (11) is a mouse monoclonal IgG2a antibody that detects GABP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GABP antibody (11) specifically targets the GABPβ subunit, which exists in two splice variants, β1 and β2, that differ in their C-termini and play crucial roles in the regulation of gene expression. GABP (11) monoclonal antibody recognizes the GABP protein complex, formed by the interaction of GABPα and GABPβ, which is essential for various cellular processes, including the transcriptional regulation of genes involved in cell growth and differentiation. GABPβ is expressed in both the cytoplasm and nucleus of primary neuronal cultures, highlighting GABPβ′s importance in coordinating mitochondrial and nuclear transcription, particularly for cytochrome oxidase in neurons. This dual localization is critical for maintaining cellular energy metabolism and ensuring proper neuronal function. GABP′s ability to form heterodimers and heterotetramers allows for versatile regulatory mechanisms, influencing the transcription of key genes such as BRCA1 in breast cells and the adenovirus E4 gene, thereby underscoring GABP′s significance in both normal physiology and disease states.

The preferred GABP-β1/2 antibody is GABP-β1/2 Antibody (E-7): sc-271571.