GABA_B R2 Antibody (H-10): sc-393270

GABAB R2 Antibody (H-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects GABAB R2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABAB R2 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABAB R2 protein is a critical component of the GABAB receptor, which is a metabotropic receptor that plays a vital role in the central nervous system by mediating slow inhibitory neurotransmission. This receptor is a heterodimer composed of GABAB R1 and GABAB R2, both of which are G protein-coupled receptors predominantly expressed in the brain. GABAB receptor′s activation leads to the modulation of various intracellular signaling pathways, including the opening of potassium channels and the inhibition of adenylyl cyclase activity, which are essential for maintaining neuronal excitability and synaptic plasticity. Proper functioning of GABAB R2 is crucial for processes such as muscle relaxation, the regulation of sleep patterns, and the modulation of pain, highlighting its importance in both physiological and pathological conditions. Using anti-GABAB R2 antibody (H-10) in research can provide valuable insights into the mechanisms of GABAergic signaling and its implications in neurological disorders.

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GABA_B R2 Antibody (H-10) References:

1. Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons.  |  Filippov, AK., et al. 2000. J Neurosci. 20: 2867-74. PMID: 10751439
2. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.  |  White, JH., et al. 2000. Proc Natl Acad Sci U S A. 97: 13967-72. PMID: 11087824
3. GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons.  |  Burman, KJ., et al. 2003. Brain Res. 970: 35-46. PMID: 12706246
4. Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking.  |  Balasubramanian, S., et al. 2004. J Biol Chem. 279: 18840-50. PMID: 14966130
5. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.  |  Brock, C., et al. 2005. Mol Biol Cell. 16: 5572-8. PMID: 16176975
6. Functional expression of the GABAB receptor in human airway smooth muscle.  |  Osawa, Y., et al. 2006. Am J Physiol Lung Cell Mol Physiol. 291: L923-31. PMID: 16829628
7. GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function.  |  Balasubramanian, S., et al. 2007. J Biol Chem. 282: 4162-71. PMID: 17145756
8. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.  |  Chang, W., et al. 2007. J Biol Chem. 282: 25030-40. PMID: 17591780
9. GABA B receptor is a novel drug target for pancreatic cancer.  |  Schuller, HM., et al. 2008. Cancer. 112: 767-78. PMID: 18098271
10. GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence.  |  Kauffman, MA., et al. 2008. Seizure. 17: 567-71. PMID: 18255321
11. Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.  |  Agrawal, A., et al. 2008. Addiction. 103: 1027-38. PMID: 18482426
12. Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model.  |  Kamel, AS., et al. 2023. Expert Opin Ther Targets. 27: 373-392. PMID: 37089040

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GABA_B R2 Antibody (H-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-GABA_B R2 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GABA_B R2 Antibody (H-10) Specifications

Alternate Product Name: GABAB R2

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 183-482

Epitope Target: GABAB R2

Epitope Species: human

Product Reactivity/Detection: GABA_B R2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for GABA_B R2 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin