GABAB R1 Antibody (C-11): sc-398901

GABAB R1 Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects GABAB R1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABAB R1 is a critical component of the GABAB receptor, which is a heterodimeric G protein-coupled receptor that plays a vital role in mediating inhibitory neurotransmission in the central nervous system. The GABAB receptor, composed of GABAB R1 and GABAB R2, is essential for various physiological processes, including the regulation of synaptic transmission, modulation of neuronal excitability, and the promotion of slow wave sleep. GABAB R1 is primarily located in the postsynaptic membrane of neurons, where GABAB R1 interacts with G proteins to initiate signaling cascades that lead to the opening of potassium channels and the inhibition of adenylyl cyclase activity. This localization is crucial as GABAB R1 allows for the precise modulation of synaptic strength and timing, which is fundamental for maintaining the balance between excitation and inhibition in the brain. Dysregulation of GABAB receptor signaling has been implicated in various neurological disorders, making GABAB R1 a significant target for therapeutic intervention. anti-GABAB R1 antibody (C-11) is an invaluable tool for researchers studying the intricate mechanisms of GABAergic signaling and its implications in health and disease.

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GABAB R1 Antibody (C-11) References:

1. Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain.  |  Bischoff, S., et al. 1999. J Comp Neurol. 412: 1-16. PMID: 10440706
2. Localization of GABA(B) (R1) receptors in the rat hippocampus by immunocytochemistry and high resolution autoradiography, with specific reference to its localization in identified hippocampal interneuron subpopulations.  |  Sloviter, RS., et al. 1999. Neuropharmacology. 38: 1707-21. PMID: 10587087
3. Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.  |  Galvez, T., et al. 2000. Mol Pharmacol. 57: 419-26. PMID: 10692480
4. Differential expression of GABA(B)R1 and GABA(B)R2 receptor immunoreactivity in neurochemically identified neurons of the rat neostriatum.  |  Ng, TK. and Yung, KK. 2001. J Comp Neurol. 433: 458-70. PMID: 11304711
5. Association of EEG coherence and an exonic GABA(B)R1 gene polymorphism.  |  Winterer, G., et al. 2003. Am J Med Genet B Neuropsychiatr Genet. 117B: 51-6. PMID: 12555235
6. The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development.  |  Ritter, B., et al. 2004. Brain Res Dev Brain Res. 149: 73-7. PMID: 15013631
7. Gradual downregulation of protein expression of the partner GABA(B)R2 subunit during postnatal brain development in mice defective of GABA(B)R1 subunit.  |  Fukui, M., et al. 2011. J Pharmacol Sci. 115: 45-55. PMID: 21160134
8. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression.  |  Kim, JY., et al. 2011. Transl Stroke Res. 2: 195-201. PMID: 21731589
9. The level and distribution of the GABA(B)R1 and GABA(B)R2 receptor subunits in the rat's inferior colliculus.  |  Jamal, L., et al. 2012. Front Neural Circuits. 6: 92. PMID: 23189044
10. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.  |  Jones, KA., et al. 1998. Nature. 396: 674-9. PMID: 9872315

The preferred GABA_B R1 antibody is GABA_B R1 Antibody (D-2): sc-166408.