GABA_A Rε Antibody (E-12): sc-271668

GABAA Rε Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects GABAA R epsilon protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABAA Rε (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABAA R epsilon protein plays a crucial role in the central nervous system as a component of the GABAA receptor, which is essential for mediating inhibitory neurotransmission. This receptor is primarily located in the postsynaptic membrane of neurons, where binding with gamma-aminobutyric acid (GABA) facilitates chloride ion influx, leading to neuron hyperpolarization and decreased neuronal excitability. Proper functioning of GABAA receptors, including GABAA R epsilon subunit, is vital for maintaining balance between excitation and inhibition in the brain, which is critical for processes such as anxiety regulation, muscle relaxation, and seizure prevention. Dysregulation of GABAA receptor activity has been implicated in various neurological disorders, making anti-GABAA R epsilon antibody (E-12) particularly important for studying interactions with other proteins, such as GAD-65 and GAD-67, to understand and potentially treat these conditions.

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GABA_A Rε Antibody (E-12) References:

1. Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.  |  Borden, LA., et al. 1992. J Biol Chem. 267: 21098-104. PMID: 1400419
2. GABA: an excitatory transmitter in early postnatal life.  |  Cherubini, E., et al. 1991. Trends Neurosci. 14: 515-9. PMID: 1726341
3. Cloning of the human brain GABA transporter.  |  Nelson, H., et al. 1990. FEBS Lett. 269: 181-4. PMID: 2387399
4. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase.  |  Dirkx, R., et al. 1995. J Biol Chem. 270: 2241-6. PMID: 7836456
5. GABAC receptors in the vertebrate retina.  |  Lukasiewicz, PD. 1996. Mol Neurobiol. 12: 181-94. PMID: 8884747
6. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.  |  Kaupmann, K., et al. 1997. Nature. 386: 239-46. PMID: 9069281
7. GABA(A)-receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands.  |  Korpi, ER., et al. 1997. Ann Med. 29: 275-82. PMID: 9375983

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GABA_A Rε Antibody (E-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GABA_A Rε Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GABA_A Rε Antibody (E-12) Specifications

Alternate Product Name: GABAA Rε

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-110

Epitope Target: GABA_A Rε

Epitope Species: human

Product Reactivity/Detection: GABA_A Rε

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GABA_A Rε Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin