Gab 3 Antibody (G-3): sc-271476

Gab 3 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects Gab3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gab3 is a member of the Gab (GRB2-associated binder)/DOS family of adaptor proteins, which play a pivotal role as molecular scaffolds that facilitate the recruitment of proteins to receptor tyrosine kinases (RTKs). This recruitment is essential for the propagation of signaling cascades initiated by cytokine and growth factor interactions with RTKs, ultimately leading to cellular responses such as activation, proliferation, and differentiation. The structure of Gab3 contains pleckstrin homology domains and potential binding sites for SH2 and SH3 domain-containing proteins, which are crucial for signaling pathways. The phosphorylation-dependent recruitment of signaling partners to Gab family members underscores the dynamic nature of these interactions, particularly in pathways like insulin receptor and epidermal growth factor receptor signaling, where Gab3 acts as a critical mediator of the nuclear response to extracellular stimuli. Mapping to chromosome Xq28, the human Gab3 gene encodes a 586 amino acid protein, highlighting its significance in cellular signaling and potential implications in various physiological and pathological processes. Anti-Gab3 antibody (G-3) serves as an invaluable tool for researchers investigating the intricate roles of Gab3 in cellular signaling networks.

The preferred Gab 3 antibody is Gab 3 Antibody (E-1): sc-271475.