G-CSFR Antibody (R12): sc-74026
- G-CSFR Antibody (R12) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against the extracellular domain of G-CSFR of human origin
- recommended for detection of G-CSFR of human origin by WB, IP and FCM; non cross-reactive with GM-CSFRα, GM-CSFRβ or M-CSFR
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for G-CSFR Antibody (R12). This work is in progress.
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SEE ALSO...
G-CSFR Antibody (R12) is a mouse monoclonal IgG1 antibody that detects G-CSFR in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). G-CSFR, or Granulocyte Colony-Stimulating Factor Receptor, plays a crucial role in hematopoiesis by mediating the effects of G-CSF, which is essential for the proliferation and differentiation of granulocyte precursors in the bone marrow. G-CSFR′s function lies in regulating the immune response and enhancing the production of neutrophils, which are vital for combating infections and inflammation. G-CSFR is primarily located on the surface of hematopoietic cells, where G-CSFR initiates signaling cascades upon ligand binding, leading to cellular responses that are critical for maintaining immune homeostasis. G-CSFR′s unique homodimeric structure, formed upon G-CSF binding, distinguishes G-CSFR from other hematopoietic receptors that typically require heteromeric complexes, highlighting G-CSFR′s specialized role in the immune system. Anti-G-CSFR antibody (R12) is an invaluable tool for researchers studying the dynamics of granulocyte production and the broader implications of G-CSF signaling in various physiological and pathological contexts.
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G-CSFR Antibody (R12) References:
- Granulocyte colony-stimulating factor receptor: structure and function. | Akbarzadeh, S. and Layton, JE. 2001. Vitam Horm. 63: 159-94. PMID: 11358114
- Granulocyte colony-stimulating factor receptor signaling: implications for G-CSF responses and leukemic progression in severe congenital neutropenia. | Touw, IP., et al. 2013. Hematol Oncol Clin North Am. 27: 61-73, viii. PMID: 23351988
- Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy. | Liongue, C. and Ward, AC. 2014. Front Oncol. 4: 93. PMID: 24822171
- Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco. | Wojtukiewicz, MZ., et al. 2016. Adv Clin Exp Med. 25: 505-11. PMID: 27629739
- Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies. | Dwivedi, P. and Greis, KD. 2017. Exp Hematol. 46: 9-20. PMID: 27789332
- Design of a recombinant immunotoxin against the human granulocyte-colony stimulating factor receptor. | Babavalian, E., et al. 2019. Mol Biol Rep. 46: 1093-1097. PMID: 30565075
- Engineering an anti-granulocyte colony stimulating factor receptor nanobody for improved affinity. | Bakherad, H., et al. 2020. Life Sci. 257: 118052. PMID: 32634431
- A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer. | Park, SD., et al. 2022. Front Oncol. 12: 932608. PMID: 36033452
- Leukemia-associated truncation of granulocyte colony-stimulating factor receptor impacts granulopoiesis throughout the life-course. | Bulleeraz, V., et al. 2022. Front Immunol. 13: 1095453. PMID: 36703974
- Granulocyte colony-stimulating factor receptor mutations in severe chronic neutropenia and acute myeloid leukaemia: biological and clinical significance. | Touw, IP. 1997. Baillieres Clin Haematol. 10: 577-87. PMID: 9421617
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
G-CSFR Antibody (R12) | sc-74026 | 100 µg/ml | $322.00 |