Fyn Antibody (G-4): sc-271293
- Fyn Antibody (G-4) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-80 mapping at the N-terminus of Fyn of human origin
- recommended for detection of Fyn of mouse, rat and human origin by WB, IP, IF and ELISA
- See Fyn (15): sc-434 for Fyn antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fyn Antibody (G-4) for WB applications. These reagents are now offered in bundles with Fyn Antibody (G-4) (see ordering information below).
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Fyn Antibody (G-4) is a mouse monoclonal IgG1 antibody that detects Fyn in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fyn is a member of the Src family of non-receptor tyrosine kinases, which play a crucial role in various cellular processes, including T-cell receptor signaling, cell proliferation, and differentiation. Fyn protein is primarily located in the cytoplasm and can translocate to the plasma membrane upon activation, which is essential for mediating signaling pathways that regulate immune responses. This dynamic localization allows Fyn to interact with various signaling molecules and adapt to different cellular contexts, thereby influencing processes such as cytoskeletal organization and cell adhesion. Anti-Fyn antibody (G-4) is particularly valuable for researchers studying T-cell signaling and its implications in immune system function and related diseases, making this tool indispensable for advancing our understanding of cellular signaling mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fyn Antibody (G-4) References:
- From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase. | Krämer-Albers, EM. and White, R. 2011. Cell Mol Life Sci. 68: 2003-12. PMID: 21207100
- Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. | Um, JW. and Strittmatter, SM. 2013. Prion. 7: 37-41. PMID: 22987042
- Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. | Burrell, TC., et al. 2014. PLoS One. 9: e110845. PMID: 25340851
- Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death. | Wang, Y., et al. 2015. J Biol Chem. 290: 24772-83. PMID: 26306048
- Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules. | Okamoto, M., et al. 2016. J Cell Biochem. 117: 894-903. PMID: 26365631
- Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. | Peckham, H., et al. 2016. Glia. 64: 255-69. PMID: 26449489
- Fyn Plays a Pivotal Role in Fetomaternal Tolerance Through Regulation of Th17 Cells. | Liu, Q., et al. 2016. Am J Reprod Immunol. 75: 569-79. PMID: 26892111
- Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3. | Seo, HY., et al. 2016. Kidney Int. 90: 1285-1297. PMID: 27616741
- Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. | Li, K., et al. 2018. Ann Rheum Dis. 77: 935-943. PMID: 29555825
- FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells. | Yu, B., et al. 2020. Cell Death Dis. 11: 652. PMID: 32811808
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fyn Antibody (G-4) | sc-271293 | 200 µg/ml | $322.00 | |||
Fyn Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-540222 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fyn Antibody (G-4): m-IgG1 BP-HRP Bundle | sc-541981 | 200 µg Ab; 20 µg BP | $361.00 |