Fyn Antibody (15): sc-434
- Fyn Antibody (15) is a mouse monoclonal IgG1 κ Fyn antibody, cited in 146 publications, provided at 200 µg/ml
- epitope mapping between amino acids 85-206 of Fyn of human origin
- Fyn Antibody (15) is recommended for detection of Fyn p59 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- Anti-Fyn Antibody (15) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Fyn Antibody (15) for WB and IHC(P) applications. These reagents are now offered in bundles with Fyn Antibody (15) (see ordering information below).
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Fyn Antibody (15) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Fyn protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Fyn (15) monoclonal antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fyn, a member of the Src family of non-receptor tyrosine kinases, plays a crucial role in T-cell receptor signaling, which is essential for the immune response. Fyn is primarily located in the cytoplasm and can translocate to the plasma membrane upon activation, where Fyn interacts with various signaling molecules to modulate cellular processes such as proliferation, differentiation, and motility. Proper localization of Fyn is vital for function, as this allows for precise regulation of signaling pathways that are critical for T-cell activation and immune responses. The human Fyn gene is located on chromosome 6q21 and encodes a 537 amino acid protein, which is involved in modulation of various cellular functions through kinase activity. Understanding the role of Fyn and localization within the cell can provide insights into contributions to immune system regulation and potential implications in diseases such as cancer and autoimmune disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fyn Antibody (15) References:
- Kinases of the Src family: structure and functions. | Tatosyan, AG. and Mizenina, OA. 2000. Biochemistry (Mosc). 65: 49-58. PMID: 10702640
- Src kinase-mediated signaling in leukocytes. | Korade-Mirnics, Z. and Corey, SJ. 2000. J Leukoc Biol. 68: 603-13. PMID: 11073097
- Selected glimpses into the activation and function of Src kinase. | Bjorge, JD., et al. 2000. Oncogene. 19: 5620-35. PMID: 11114743
- SRC family kinases mediate epithelial Na+ channel inhibition by endothelin. | Gilmore, ES., et al. 2001. J Biol Chem. 276: 42610-7. PMID: 11560932
- Fyn in Neurodevelopment and Ischemic Brain Injury. | Knox, R. and Jiang, X. 2015. Dev Neurosci. 37: 311-20. PMID: 25720756
- Targeting Fyn Kinase in Alzheimer's Disease. | Nygaard, HB. 2018. Biol Psychiatry. 83: 369-376. PMID: 28709498
- Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease. | Panicker, N., et al. 2019. Aging (Albany NY). 11: 5871-5873. PMID: 31454793
- FYN: emerging biological roles and potential therapeutic targets in cancer. | Peng, S. and Fu, Y. 2023. J Transl Med. 21: 84. PMID: 36740671
- FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer. | Peng, S., et al. 2023. J Exp Clin Cancer Res. 42: 80. PMID: 37016377
- Lyn, a src-like tyrosine kinase. | Hibbs, ML. and Dunn, AR. 1997. Int J Biochem Cell Biol. 29: 397-400. PMID: 9202419
- Insights into Src kinase functions: structural comparisons. | Williams, JC., et al. 1998. Trends Biochem Sci. 23: 179-84. PMID: 9612082
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fyn Antibody (15) | sc-434 | 200 µg/ml | $322.00 | |||
Fyn Antibody (15): m-IgG Fc BP-HRP Bundle | sc-528110 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fyn Antibody (15): m-IgGκ BP-HRP Bundle | sc-520409 | 200 µg Ab, 40 µg BP | $361.00 | |||
Fyn Antibody (15): m-IgG1 BP-HRP Bundle | sc-542764 | 200 µg Ab; 20 µg BP | $361.00 | |||
Fyn Antibody (15) AC | sc-434 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Fyn Antibody (15) HRP | sc-434 HRP | 200 µg/ml | $322.00 | |||
Fyn Antibody (15) FITC | sc-434 FITC | 200 µg/ml | $336.00 | |||
Fyn Antibody (15) PE | sc-434 PE | 200 µg/ml | $349.00 | |||
Fyn Antibody (15) Alexa Fluor® 488 | sc-434 AF488 | 200 µg/ml | $364.00 | |||
Fyn Antibody (15) Alexa Fluor® 546 | sc-434 AF546 | 200 µg/ml | $364.00 | |||
Fyn Antibody (15) Alexa Fluor® 594 | sc-434 AF594 | 200 µg/ml | $364.00 | |||
Fyn Antibody (15) Alexa Fluor® 647 | sc-434 AF647 | 200 µg/ml | $364.00 | |||
Fyn Antibody (15) Alexa Fluor® 680 | sc-434 AF680 | 200 µg/ml | $364.00 | |||
Fyn Antibody (15) Alexa Fluor® 790 | sc-434 AF790 | 200 µg/ml | $364.00 |