Fyb Antibody (5): sc-135913
- Fyb Antibody (5) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 673-783 of Fyb of human origin
- recommended for detection of Fyb of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fyb Antibody (5). This work is in progress.
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Fyb Antibody (5) is a mouse monoclonal IgG1 antibody that detects Fyb in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Fyb, or Fyn binding protein, plays a crucial role in T cell signaling by interacting with the tyrosine kinase p59fyn and anchoring proteins like SKAP55 and SKAP55-R. Fyb is primarily located in the cytoplasm, where Fyb facilitates the assembly of signaling complexes essential for T cell activation. This localization allows Fyb to effectively mediate downstream signaling pathways initiated by lymphocyte antigen receptors, which are critical for immune responses. The human Fyb gene, located on chromosome 5p13.1, encodes a 783 amino acid protein featuring a unique structure, including an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif. These structural elements enable Fyb to interact with other signaling molecules, thereby influencing T cell function and contributing to immune response regulation. Anti-Fyb antibody (5) serves as an invaluable tool for researchers studying T cell signaling and its implications in immune-related diseases.
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Fyb Antibody (5) References:
- Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. | Griffiths, EK. and Penninger, JM. 2002. Curr Opin Immunol. 14: 317-22. PMID: 11973129
- A second example of anti-Fyb. | LEVINE, P., et al. 1955. Blood. 10: 941-4. PMID: 13250039
- FYB gene polymorphisms are associated with susceptibility for systemic lupus erythemathosus (SLE). | Addobbati, C., et al. 2013. Hum Immunol. 74: 1009-14. PMID: 23628395
- Neutrophil cell surface receptors and their intracellular signal transduction pathways. | Futosi, K., et al. 2013. Int Immunopharmacol. 17: 638-50. PMID: 23994464
- Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. | Levin, C., et al. 2015. J Thromb Haemost. 13: 1285-92. PMID: 25876182
- Assessment of calciprotein particle formation by AUC of the absorbance change: effect of FYB-931, a novel bisphosphonate compound. | Ishida, K., et al. 2021. J Pharm Pharmacol. 73: 947-955. PMID: 33882129
- Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis via Microarray Data Analysis. | Su, W., et al. 2021. Front Immunol. 12: 667690. PMID: 34122426
- FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population. | Li, M., et al. 2022. Biomarkers. 27: 79-85. PMID: 34882057
- Red Cell Antigens and Antibodies. | Lomas-Francis, C. and Westhoff, CM. 2022. Hematol Oncol Clin North Am. 36: 283-291. PMID: 35282947
- FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. | Liu, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 8779-84. PMID: 9671755
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fyb Antibody (5) | sc-135913 | 50 µg/0.5 ml | $316.00 |