FXR2 Antibody (1G2): sc-32266
- FXR2 Antibody (1G2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 414-658 of FXR2 of human origin
- Anti-FXR2 Antibody (1G2) is recommended for detection of FXR2 of mouse, rat and human origin by WB, IP and IF
- Anti-FXR2 Antibody (1G2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FXR2 Antibody (1G2) for WB applications. These reagents are now offered in bundles with FXR2 Antibody (1G2) (see ordering information below).
QUICK LINKS
FXR2 Antibody (1G2) is a mouse monoclonal IgG1 kappa light chain antibody that detects FXR2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-FXR2 antibody (1G2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FXR2, or Fragile X Mental Retardation 2, plays a crucial role in regulating mRNA translation and is essential for neuronal development and function. FXR2 interacts with the FMR1 protein, which is involved in the pathophysiology of Fragile X syndrome, the most common form of inherited intellectual disability. FXR2 is primarily located in the cytoplasm, where FXR2 associates with polyribosomes, facilitating the translation of specific mRNAs that are vital for synaptic plasticity and neuronal signaling. Proper localization and function of FXR2 are critical, as dysregulation can lead to impaired cognitive functions and contribute to the severity of Fragile X syndrome. Using FXR2 (1G2) antibody in your research can provide valuable insights into the molecular mechanisms underlying these neurological conditions and explore potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FXR2 Antibody (1G2) References:
- Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P. | Tamanini, F., et al. 1999. Biochem J. 343 Pt 3: 517-23. PMID: 10527928
- Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. | Ceman, S., et al. 1999. Mol Cell Biol. 19: 7925-32. PMID: 10567518
- Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. | Verkerk, AJ., et al. 1991. Cell. 65: 905-14. PMID: 1710175
- Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. | Matunis, MJ., et al. 1992. Mol Cell Biol. 12: 164-71. PMID: 1729596
- Absence of expression of the FMR-1 gene in fragile X syndrome. | Pieretti, M., et al. 1991. Cell. 66: 817-22. PMID: 1878973
- The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. | Zhang, Y., et al. 1995. EMBO J. 14: 5358-66. PMID: 7489725
- A point mutation in the FMR-1 gene associated with fragile X mental retardation. | De Boulle, K., et al. 1993. Nat Genet. 3: 31-5. PMID: 8490650
- The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. | Eberhart, DE., et al. 1996. Hum Mol Genet. 5: 1083-91. PMID: 8842725
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FXR2 Antibody (1G2) | sc-32266 | 200 µg/ml | $316.00 | |||
FXR2 Antibody (1G2): m-IgG Fc BP-HRP Bundle | sc-528449 | 200 µg Ab; 10 µg BP | $354.00 | |||
FXR2 Antibody (1G2): m-IgGκ BP-HRP Bundle | sc-520829 | 200 µg Ab, 40 µg BP | $354.00 | |||
FXR2 Antibody (1G2): m-IgG1 BP-HRP Bundle | sc-542936 | 200 µg Ab; 20 µg BP | $354.00 | |||
FXR2 Antibody (1G2) AC | sc-32266 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FXR2 Antibody (1G2) HRP | sc-32266 HRP | 200 µg/ml | $316.00 | |||
FXR2 Antibody (1G2) FITC | sc-32266 FITC | 200 µg/ml | $330.00 | |||
FXR2 Antibody (1G2) PE | sc-32266 PE | 200 µg/ml | $343.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 488 | sc-32266 AF488 | 200 µg/ml | $357.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 546 | sc-32266 AF546 | 200 µg/ml | $357.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 594 | sc-32266 AF594 | 200 µg/ml | $357.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 647 | sc-32266 AF647 | 200 µg/ml | $357.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 680 | sc-32266 AF680 | 200 µg/ml | $357.00 | |||
FXR2 Antibody (1G2) Alexa Fluor® 790 | sc-32266 AF790 | 200 µg/ml | $357.00 |