FUS/TLS Antibody (4H11): sc-47711

FUS/TLS Antibody (4H11) is a mouse monoclonal IgG1 kappa light chain antibody that detects FUS/TLS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-FUS/TLS antibody (4H11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FUS/TLS protein, also known as heterogeneous nuclear ribonucleoprotein (hnRNP) complex component, plays a crucial role in RNA processing and transport within the nucleus. FUS/TLS protein is involved in the regulation of gene expression by binding to RNA and influencing RNA stability and localization. This function is particularly important in cellular responses to stress and during cancer development, where aberrant RNA processing can lead to oncogenic transformations. FUS/TLS protein interacts with various nuclear steroid receptors, suggesting involvement in hormone-induced transcriptional regulation. Additionally, FUS/TLS protein is implicated in chromosomal translocations that result in fusion proteins, such as EWS/Fli-1 chimeric protein, which acts as a potent transcriptional activator in Ewing sarcoma. Understanding FUS/TLS protein′s role in these processes is essential for elucidating contributions to both normal cellular function and disease mechanisms.

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FUS/TLS Antibody (4H11) References:

1. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.  |  Delattre, O., et al. 1992. Nature. 359: 162-5. PMID: 1522903
2. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.  |  Kwiatkowski, TJ., et al. 2009. Science. 323: 1205-8. PMID: 19251627
3. Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases: an expert TLS panel consensus.  |  Cairo, MS., et al. 2010. Br J Haematol. 149: 578-86. PMID: 20331465
4. Functions of FUS/TLS from DNA repair to stress response: implications for ALS.  |  Sama, RR., et al. 2014. ASN Neuro. 6: PMID: 25289647
5. Hypoxia-Induced FUS-circTBC1D14 Stress Granules Promote Autophagy in TNBC.  |  Liu, Y., et al. 2023. Adv Sci (Weinh). 10: e2204988. PMID: 36806670
6. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer.  |  He, M., et al. 2023. J Immunother Cancer. 11: PMID: 37072348
7. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.  |  Jeon, IS., et al. 1995. Oncogene. 10: 1229-34. PMID: 7700648
8. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.  |  May, WA., et al. 1993. Mol Cell Biol. 13: 7393-8. PMID: 8246959
9. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.  |  Crozat, A., et al. 1993. Nature. 363: 640-4. PMID: 8510758
10. The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator.  |  Fujimura, Y., et al. 1996. Oncogene. 12: 159-67. PMID: 8552387
11. A new member of the ETS family fused to EWS in Ewing tumors.  |  Peter, M., et al. 1997. Oncogene. 14: 1159-64. PMID: 9121764
12. TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.  |  Powers, CA., et al. 1998. Mol Endocrinol. 12: 4-18. PMID: 9440806

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FUS/TLS Antibody (4H11) has 160 citations in a variety of scientific publications.

Primary antibodies like Anti-FUS/TLS Antibody (4H11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FUS/TLS Antibody (4H11) Specifications

Alternate Product Name: hnRNP complex TLS / FUS

Product Clone Name: 4H11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: FUS/TLS

Epitope Species: human

Product Reactivity/Detection: FUS/TLS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 160 citations in various scientific publications

Available Conjugates/Forms for FUS/TLS Antibody (4H11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin