FucT-IV Antibody (MY-1): sc-59531
- FucT-IV Antibody (MY-1) is a mouse monoclonal IgM provided at 500 µl supernatant
- raised against purified neutrophils from peripheral blood of human origin
- recommended for detection of FucT-IV of human origin by IF and IHC(P); also recommended for detection of an antigen located on mature granulocytes and on Hodgkin and Reed Sternberg cells
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FucT-IV Antibody (MY-1). This work is in progress.
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FucT-IV Antibody (MY-1) is a mouse monoclonal IgM antibody that detects FucT-IV of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-FucT-IV antibody (MY-1) is available in a non-conjugated form, allowing for versatile applications in research. FucT-IV, also known as FUT4, FCT3A, or ELFT, is a 405 amino acid single-pass type II membrane protein primarily localized to Golgi stacks. Such localization positions FucT-IV at glycosylation sites, where FucT-IV catalyzes fucose addition to various glycan structures, including N-acetyllactosamines. FucT-IV enzymatic activity is essential for synthesizing complex carbohydrates, such as cell-adhesion antigen CD15 (Lewis X), which plays a significant role in cell-cell interactions and signaling pathways, including apoptosis and cellular adhesion. FucT-IV shows high expression during embryogenesis in tissues such as skin, liver, kidney, muscle, and small intestine, highlighting FucT-IV importance in developmental processes. FucT-IV overexpression has been linked to epithelial cancers, suggesting potential involvement in tumorigenesis and making FucT-IV a valuable target for cancer research.
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FucT-IV Antibody (MY-1) References:
- A GDP-fucose-protected, pyridoxal-5'-Phosphate/NaBH(4)-sensitive lys residue common to human alpha1-->3Fucosyltransferases corresponds to Lys(300) in FucT-IV. | Sherwood, AL., et al. 2000. Biochem Biophys Res Commun. 273: 870-6. PMID: 10891339
- The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. | Homeister, JW., et al. 2001. Immunity. 15: 115-26. PMID: 11485743
- Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. | Burne, MJ. and Rabb, H. 2002. J Immunol. 169: 2648-52. PMID: 12193737
- Glycosylation in the control of selectin counter-receptor structure and function. | Lowe, JB. 2002. Immunol Rev. 186: 19-36. PMID: 12234359
- Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. | Martinez, M., et al. 2005. J Biol Chem. 280: 5378-90. PMID: 15579466
- Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IV. | Holmes, EH., et al. 1995. J Biol Chem. 270: 8145-51. PMID: 7713918
- The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. | Knibbs, RN., et al. 1996. J Cell Biol. 133: 911-20. PMID: 8666674
- An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin. | Wagers, AJ., et al. 1996. Blood. 88: 2125-32. PMID: 8822932
- Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes. | Wagers, AJ., et al. 1997. J Immunol. 159: 1917-29. PMID: 9257857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FucT-IV Antibody (MY-1) | sc-59531 | 500 µl supernatant | $316.00 |