FRP-3 Antibody (B-5): sc-514350

FRP-3 Antibody (B-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects FRP-3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FRP-3 (B-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FRP-3 plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions, including cell proliferation, differentiation, and tissue homeostasis. Specifically, FRP-3 acts as a secreted antagonist that modulates the activity of Wnt proteins by binding to frizzled receptors, thereby regulating the levels of β-catenin in the cytoplasm. This regulation is vital because aberrations in Wnt signaling have been implicated in numerous diseases, including cancer and developmental disorders. FRP-3 expression is particularly high in developing tissues, highlighting its importance during embryogenesis and tissue formation. Anti-FRP-3 antibody (B-5) enables researchers to gain insights into the mechanisms of Wnt signaling and its implications in health and disease.

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FRP-3 Antibody (B-5) References:

1. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.  |  Chang, JT., et al. 1999. Hum Mol Genet. 8: 575-83. PMID: 10072424
2. Effect of cellular function inhibitors on the infection of Frp/3 cells by hepatitis A virus.  |  Superti, F., et al. 1989. Med Microbiol Immunol. 178: 29-36. PMID: 2535886
3. Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus.  |  Superti, F., et al. 1989. Antiviral Res. 11: 247-54. PMID: 2552913
4. Isolation of hepatitis A virus from polluted river water on FRP/3 cells.  |  Panà, A., et al. 1987. Lancet. 2: 1328. PMID: 2890922
5. Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus.  |  Seganti, L., et al. 1987. Med Microbiol Immunol. 176: 21-6. PMID: 3029555
6. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.  |  Wang, Y., et al. 1996. J Biol Chem. 271: 4468-76. PMID: 8626800
7. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
8. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.  |  Rattner, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2859-63. PMID: 9096311
9. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.  |  Finch, PW., et al. 1997. Proc Natl Acad Sci U S A. 94: 6770-5. PMID: 9192640
10. SARPs: a family of secreted apoptosis-related proteins.  |  Melkonyan, HS., et al. 1997. Proc Natl Acad Sci U S A. 94: 13636-41. PMID: 9391078
11. Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.  |  Leimeister, C., et al. 1998. Mech Dev. 75: 29-42. PMID: 9739103
12. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.  |  Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FRP-3 Antibody (B-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FRP-3 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FRP-3 Antibody (B-5) Specifications

Alternate Product Name: FRP-3

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 156-325

Epitope Target: FRP-3

Epitope Species: human

Product Reactivity/Detection: FRP-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FRP-3 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin