FRP-2 Antibody (C-4): sc-365524

FRP-2 Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects FRP-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FRP-2 Antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FRP-2 protein plays a crucial role in the Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and tissue homeostasis. By regulating intracellular levels of β-catenin, FRP-2 influences gene expression and developmental processes, making FRP-2 vital for normal embryonic development and maintenance of adult tissues. Frizzled-related proteins, including FRP-2, are secreted proteins that share homology with the cysteine-rich, ligand-binding domain of frizzled receptors, allowing FRP-2 to modulate Wnt signaling effectively. Expression of FRP-2 is particularly high in developing tissues, highlighting FRP-2′s importance during critical stages of growth and development. With an ability to interact with various components of the Wnt pathway, anti-FRP-2 antibody (C-4) serves as a valuable tool for researchers investigating the complexities of cellular signaling and development.

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FRP-2 Antibody (C-4) References:

1. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.  |  Chang, JT., et al. 1999. Hum Mol Genet. 8: 575-83. PMID: 10072424
2. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.  |  Kaur, A., et al. 2016. Nature. 532: 250-4. PMID: 27042933
3. Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin.  |  Tabib, T., et al. 2021. Nat Commun. 12: 4384. PMID: 34282151
4. SFRP2 Improves Mitochondrial Dynamics and Mitochondrial Biogenesis, Oxidative Stress, and Apoptosis in Diabetic Cardiomyopathy.  |  Ma, T., et al. 2021. Oxid Med Cell Longev. 2021: 9265016. PMID: 34790288
5. A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.  |  Cohen, ML., et al. 2024. J Clin Invest. 134: PMID: 38980870
6. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.  |  Wang, Y., et al. 1996. J Biol Chem. 271: 4468-76. PMID: 8626800
7. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
8. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.  |  Rattner, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2859-63. PMID: 9096311
9. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.  |  Finch, PW., et al. 1997. Proc Natl Acad Sci U S A. 94: 6770-5. PMID: 9192640
10. SARPs: a family of secreted apoptosis-related proteins.  |  Melkonyan, HS., et al. 1997. Proc Natl Acad Sci U S A. 94: 13636-41. PMID: 9391078
11. Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.  |  Leimeister, C., et al. 1998. Mech Dev. 75: 29-42. PMID: 9739103
12. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.  |  Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FRP-2 Antibody (C-4) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-FRP-2 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FRP-2 Antibody (C-4) Specifications

Alternate Product Name: FRP-2

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 156-295

Epitope Target: FRP-2

Epitope Species: human

Product Reactivity/Detection: FRP-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for FRP-2 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin