frizzled-7 Antibody (4D9): sc-293261

frizzled-7 Antibody (4D9) is a mouse monoclonal IgG1 kappa light chain antibody that detects frizzled-7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-frizzled-7 antibody (4D9) is available as the non-conjugated format. frizzled-7 protein plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions, including cell proliferation, differentiation, and tissue homeostasis. frizzled-7 is characterized by seven transmembrane domains and a unique cysteine-rich domain in the extracellular region, which are vital for its function as a receptor for Wnt ligands. frizzled-7 activation leads to the modulation of beta-catenin signaling, influencing gene expression and cellular behavior. frizzled-7 is predominantly expressed in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain, and placenta, and has been specifically associated with squamous cell esophageal carcinomas, highlighting its potential as a biomarker in cancer research.

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frizzled-7 Antibody (4D9) References:

1. Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression.  |  Vincan, E., et al. 2007. Front Biosci. 12: 4558-67. PMID: 17485397
2. Frizzled7 as an emerging target for cancer therapy.  |  King, TD., et al. 2012. Cell Signal. 24: 846-51. PMID: 22182510
3. Frizzled-7 mediates TGF-β-induced pulmonary fibrosis by transmitting non-canonical Wnt signaling.  |  Guan, S. and Zhou, J. 2017. Exp Cell Res. 359: 226-234. PMID: 28736081
4. Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis.  |  Wang, Y., et al. 2021. Cancer Res. 81: 384-399. PMID: 33172933
5. Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer.  |  Atwani, R., et al. 2024. J Exp Clin Cancer Res. 43: 156. PMID: 38822429
6. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.  |  Wang, Y., et al. 1996. J Biol Chem. 271: 4468-76. PMID: 8626800
7. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
8. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.  |  Rattner, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2859-63. PMID: 9096311
9. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.  |  Finch, PW., et al. 1997. Proc Natl Acad Sci U S A. 94: 6770-5. PMID: 9192640
10. SARPs: a family of secreted apoptosis-related proteins.  |  Melkonyan, HS., et al. 1997. Proc Natl Acad Sci U S A. 94: 13636-41. PMID: 9391078
11. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.  |  Tanaka, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 10164-9. PMID: 9707618
12. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.  |  Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-frizzled-7 Antibody (4D9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-frizzled-7 Antibody (4D9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

frizzled-7 Antibody (4D9) Specifications

Alternate Product Name: frizzled-7

Product Clone Name: 4D9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 155-253

Epitope Target: frizzled-7

Epitope Species: human

Product Reactivity/Detection: frizzled-7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for frizzled-7 Antibody (4D9): N/A