frizzled-6 Antibody (D-2): sc-393113
- frizzled-6 Antibody (D-2) is a mouse monoclonal mouse IgM κ κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 51-150 mapping within an N-terminal extracellular domain of frizzled-6 of human origin
- recommended for detection of frizzled-6 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for frizzled-6 Antibody (D-2). This work is in progress.
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frizzled-6 Antibody (D-2) is a mouse monoclonal IgM antibody that detects frizzled-6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Frizzled-6 is a crucial seven-transmembrane domain receptor that plays a significant role in binding Wnt ligands, which are essential for various developmental processes, including macroscopic hair patterning and tissue polarity events. Frizzled-6′s structure features a signal peptide and a cysteine-rich domain in its N-terminal extracellular region, which is vital for interaction with Wnt-4, particularly in Madin-Darby canine kidney (MDCK) cells that can form tubules in vitro. Notably, frizzled-6 does not possess a C-terminal PDZ domain-binding motif, which distinguishes frizzled-6 from other members of the frizzled family. This receptor is expressed as a 4.4 kb mRNA across various human tissues, including the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine, and colon, highlighting frizzled-6′s widespread importance in cellular signaling and development. anti-frizzled-6 antibody (D-2) is an invaluable tool for researchers investigating the intricate roles of Wnt signaling in health and disease.
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frizzled-6 Antibody (D-2) References:
- Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal. | Abidin, BM., et al. 2015. J Immunol. 195: 2168-76. PMID: 26188064
- Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. | Dong, B., et al. 2018. Development. 145: PMID: 30237242
- Frizzled 6 disruption suppresses osteoblast differentiation induced by nanotopography through the canonical Wnt signaling pathway. | Abuna, RPF., et al. 2020. J Cell Physiol. 235: 8293-8303. PMID: 32239701
- MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in OSCC. | Sun, S., et al. 2021. J Dent Res. 100: 739-745. PMID: 33478325
- PD-L1 interacts with Frizzled 6 to activate β-catenin and form a positive feedback loop to promote cancer stem cell expansion. | Fu, L., et al. 2022. Oncogene. 41: 1100-1113. PMID: 35034965
- Zinc finger protein 501 maintains glioblastoma cell growth through enhancing Frizzled-6 expression. | Zheng, H., et al. 2022. Neurosci Res. 182: 15-24. PMID: 35688290
- Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis. | Nguyen, TH., et al. 2022. Stem Cell Reports. 17: 2303-2317. PMID: 36084638
- Frizzled 6 mutation regulates reserpine-induced depression-like behavior and Wnt signaling pathway in mice. | Yan, X., et al. 2023. Eur J Pharmacol. 957: 175996. PMID: 37597646
- miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6. | Hong, SA., et al. 2023. Sci Rep. 13: 17480. PMID: 37838767
- Frizzled 6 endows high-grade serous ovarian cancer with stem-like properties and chemoresistance. | Chen, S., et al. 2024. Mol Carcinog. 63: 2001-2012. PMID: 39129468
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
frizzled-6 Antibody (D-2) | sc-393113 | 200 µg/ml | $316.00 |