FRG1 Antibody (C-5): sc-377040

FRG1 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects FRG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FRG1 antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FRG1 protein, consisting of 258 amino acids, is a nuclear protein encoded by the human gene FRG1 and plays a crucial role in the processing of pre-ribosomal RNA, which is essential for the assembly of ribosomal subunits. This function is particularly important as FRG1 directly impacts protein synthesis within the cell, influencing cellular growth and function. Dysregulation of FRG1 has been implicated in facioscapulohumeral muscular dystrophy (FSHD), a genetic disorder characterized by muscle degeneration and retinal vascular abnormalities, which arise from increased expression of genes near the deletion on chromosome 4q35 that includes the FRG1 gene. FRG1 is expressed in various tissues, including adult and fetal muscle, lymphocytes, and placenta, and is localized to nuclear Cajal bodies or speckles, highlighting FRG1′s significance in cellular processes.

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FRG1 Antibody (C-5) References:

1. FRG1P is localised in the nucleolus, Cajal bodies, and speckles.  |  van Koningsbruggen, S., et al. 2004. J Med Genet. 41: e46. PMID: 15060122
2. The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres.  |  Tam, R., et al. 2004. J Cell Biol. 167: 269-79. PMID: 15504910
3. Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1.  |  Gabellini, D., et al. 2006. Nature. 439: 973-7. PMID: 16341202
4. Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy.  |  Osborne, RJ., et al. 2007. Neurology. 68: 569-77. PMID: 17151338
5. Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35.  |  van Deutekom, JC., et al. 1996. Hum Mol Genet. 5: 581-90. PMID: 8733123
6. The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal to the myodystrophy mutation on chromosome 8.  |  Grewal, PK., et al. 1997. Mamm Genome. 8: 394-8. PMID: 9166581
7. FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates.  |  Grewal, PK., et al. 1998. Gene. 216: 13-9. PMID: 9714712
8. Recent amplification of the human FRG1 gene during primate evolution.  |  Grewal, PK., et al. 1999. Gene. 227: 79-88. PMID: 9931447

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FRG1 Antibody (C-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FRG1 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FRG1 Antibody (C-5) Specifications

Alternate Product Name: FRG1

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-258

Epitope Target: FRG1

Epitope Species: human

Product Reactivity/Detection: FRG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FRG1 Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin