FPR2 Antibody (GM1D6): sc-57141

FPR2 Antibody (GM1D6) is a mouse monoclonal IgG1 kappa light chain antibody that detects FPR2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-FPR2 antibody (GM1D6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The N-formyl peptide receptor (FPR) family, which includes FPR2, is composed of three members: FPR, FPR-like 1 (FPRL1), and FPR-like 2 (FPRL2). These receptors are integral to the immune response, functioning as chemotactic G protein-coupled receptors with seven transmembrane domains, predominantly located on the surface of phagocytic leukocytes such as neutrophils and monocytes. FPR2 plays a crucial role in mediating inflammatory responses and host defense mechanisms by binding to various ligands, including lipoxin A4 and N-formyl-methionyl-leucyl-phenylalanine (fMLP). Upon activation, FPR2 triggers cellular migration and calcium mobilization, which are vital for effective immune responses. Notably, FPR2′s interaction with specific ligands is essential for its function, as FPR2 helps regulate inflammation and may influence the progression of diseases such as Alzheimer′s. The ability of FPR2 to modulate immune cell activity makes FPR2 a significant target for therapeutic interventions aimed at controlling inflammation and enhancing host defense.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FPR2 Antibody (GM1D6) References:

1. Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.  |  Shen, W., et al. 2000. Biochem Biophys Res Commun. 272: 276-83. PMID: 10872839
2. The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.  |  Le, Y., et al. 2001. J Immunol. 166: 1448-51. PMID: 11160182
3. Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.  |  Le, Y., et al. 2001. J Neurosci. 21: RC123. PMID: 11160457
4. Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages.  |  Yang, D., et al. 2001. J Immunol. 166: 4092-8. PMID: 11238658
5. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.  |  Christophe, T., et al. 2001. J Biol Chem. 276: 21585-93. PMID: 11285256
6. Pleiotropic roles of formyl peptide receptors.  |  Le, Y., et al. 2001. Cytokine Growth Factor Rev. 12: 91-105. PMID: 11312121
7. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1.  |  Hu, JY., et al. 2001. J Leukoc Biol. 70: 155-61. PMID: 11435499
8. FPR2: A Novel Promising Target for the Treatment of Influenza.  |  Alessi, MC., et al. 2017. Front Microbiol. 8: 1719. PMID: 28928730
9. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway.  |  Xu, X., et al. 2021. J Neuroinflammation. 18: 119. PMID: 34022892
10. FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner.  |  He, F., et al. 2023. Cancer Res. 83: 1628-1645. PMID: 36919330
11. Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation.  |  Wu, MY., et al. 2023. EMBO Mol Med. 15: e17815. PMID: 37994307
12. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.  |  Gerard, NP., et al. 1993. Biochemistry. 32: 1243-50. PMID: 8383526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FPR2 Antibody (GM1D6) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-FPR2 Antibody (GM1D6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FPR2 Antibody (GM1D6) Specifications

Alternate Product Name: Formyl Peptide Receptor 2

Product Clone Name: GM1D6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: FPR2

Epitope Species: human

Product Reactivity/Detection: FPR2 transiently expressed on the cell surface of transfected BOSC cells.

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for FPR2 Antibody (GM1D6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin