FOXQ1 Antibody (C-9): sc-166265

FOXQ1 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXQ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXQ1 Antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXQ1 plays a crucial role in regulating gene expression during embryonic development and is involved in various cellular processes, including metabolism and cancer progression. FOXQ1 interacts with several key proteins, such as transcriptional co-activator p300 and chromatin remodeling factor BRG1, which are essential for modulating transcriptional activity and chromatin structure. These interactions highlight FOXQ1′s importance in developmental pathways and potential implications in oncogenesis, particularly in colorectal adenocarcinoma and lung carcinoma, where FOXQ1 shows overexpression. FOXQ1 exhibits a tissue-restricted expression pattern, predominantly found in stomach, trachea, bladder, and salivary glands, underscoring specialized functions in these tissues. FOXQ1′s significance in lymphocyte development is demonstrated by mutation in satin homozygous mice, which exhibit defects in natural killer cell function and T-cell cytotoxicity, emphasizing FOXQ1′s role in immune regulation.

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FOXQ1 Antibody (C-9) References:

1. Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes.  |  Hoggatt, AM., et al. 2000. J Biol Chem. 275: 31162-70. PMID: 10896677
2. The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice.  |  Hong, HK., et al. 2001. Genesis. 29: 163-71. PMID: 11309849
3. Isolation and characterization of the human forkhead gene FOXQ1.  |  Bieller, A., et al. 2001. DNA Cell Biol. 20: 555-61. PMID: 11747606
4. Human FOX gene family (Review).  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1495-500. PMID: 15492844
5. Forkhead transcription factors in immunology.  |  Jonsson, H. and Peng, SL. 2005. Cell Mol Life Sci. 62: 397-409. PMID: 15719167
6. Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation.  |  Potter, CS., et al. 2006. J Biol Chem. 281: 29245-55. PMID: 16835220
7. FOXQ1 promotes esophageal cancer proliferation and metastasis by negatively modulating CDH1.  |  Pei, Y., et al. 2015. Biomed Pharmacother. 74: 89-94. PMID: 26349968
8. FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma.  |  Liu, JY., et al. 2017. Am J Transl Res. 9: 2207-2218. PMID: 28559972
9. The role of Foxq1 in proliferation of human dental pulp stem cell.  |  Tu, S., et al. 2018. Biochem Biophys Res Commun. 497: 543-549. PMID: 29453987
10. FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting β-catenin nuclear translocation.  |  Yang, M., et al. 2022. J Exp Clin Cancer Res. 41: 70. PMID: 35183223
11. The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription Factor FOXQ1 to Promote Breast Cancer Cell Growth.  |  Lin, Y., et al. 2023. Int J Biol Sci. 19: 744-759. PMID: 36778115
12. The tumor suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1.  |  Pizzolato, G., et al. 2024. J Biol Chem. 300: 107126. PMID: 38432629

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXQ1 Antibody (C-9) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXQ1 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXQ1 Antibody (C-9) Specifications

Alternate Product Name: FOXQ1

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 176-202

Epitope Target: FOXQ1

Epitope Species: human

Product Reactivity/Detection: FOXQ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for FOXQ1 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent