FOXK1 Antibody (G-4): sc-373810

FOXK1 Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXK1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-FOXK1 antibody (G-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXK1 is a member of the forkhead box (FOX) family of transcription factors, characterized by a conserved winged-helix or forkhead domain that plays a crucial role in DNA binding and gene regulation. FOXK1 is particularly important in skeletal muscle regeneration, being expressed in undifferentiated myogenic stem cells, known as satellite cells, which are essential for myofiber repair and regeneration following injury. Through interaction with cyclin-dependent kinase inhibitor p21 (CIP), FOXK1 regulates cell cycle responses during muscle regeneration. Loss of FOXK1 function in animal models has been linked to significant growth retardation and impaired muscle regeneration, highlighting a critical role in tissue repair. FOXK1 is expressed in various immature tissues, including brain, eye, heart, lung, and thymus, and is predominantly found in many malignant tissues, such as tumors of brain, colon, and lymph nodes, making FOXK1 a potential biomarker for cancer research.

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FOXK1 Antibody (G-4) References:

1. The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B.  |  Yang, Q., et al. 2000. Biochem J. 345 Pt 2: 335-43. PMID: 10620510
2. The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking.  |  Zhang, Q., et al. 2002. Hum Mol Genet. 11: 697-706. PMID: 11912185
3. Absence of p21CIP rescues myogenic progenitor cell proliferative and regenerative capacity in Foxk1 null mice.  |  Hawke, TJ., et al. 2003. J Biol Chem. 278: 4015-20. PMID: 12446708
4. Identification and characterization of a novel human FOXK1 gene in silico.  |  Huang, JT. and Lee, V. 2004. Int J Oncol. 25: 751-7. PMID: 15289879
5. Cellular and molecular regulation of skeletal muscle side population cells.  |  Meeson, AP., et al. 2004. Stem Cells. 22: 1305-20. PMID: 15579648
6. Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.  |  Garry, DJ., et al. 1997. Dev Biol. 188: 280-94. PMID: 9268575
7. Transient expression of a winged-helix protein, MNF-beta, during myogenesis.  |  Yang, Q., et al. 1997. Mol Cell Biol. 17: 5236-43. PMID: 9271401

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXK1 Antibody (G-4) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXK1 Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXK1 Antibody (G-4) Specifications

Alternate Product Name: FOXK1

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 472-611

Epitope Target: FOXK1

Epitope Species: human

Product Reactivity/Detection: Forkhead box protein K1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for FOXK1 Antibody (G-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent