FOXE3 Antibody (D-6): sc-377465

FOXE3 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects FOXE3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXE3 is a 288-amino acid winged-helix transcription factor that plays a pivotal role in the early stages of lens development, particularly in the closure of the lens vesicle. FOXE3 not only promotes the survival and proliferation of lens epithelial cells but also prevents their differentiation, ensuring proper formation of the lens. As lens fiber cells begin to differentiate, FOXE3 expression is restricted to the undifferentiated cells on the anterior surface of the lens, highlighting FOXE3′s importance in maintaining the lens′s structural integrity during development. Mutations in the FOXE3 gene can lead to congenital primary aphakia, a rare condition characterized by the absence of a lens, typically arising from a null mutation during the fourth or fifth week of human embryogenesis. Anti-FOXE3 antibody (D-6) is an essential tool for researchers studying lens development and related disorders, providing insights into the molecular mechanisms underlying these processes.

The preferred FOXE3 antibody is FOXE3 Antibody (G-1): sc-393526.