FOXE3 Antibody (G-1): sc-393526
- FOXE3 Antibody (G-1) is a mouse monoclonal IgM κ FOXE3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 224-245 near the C-terminus of FOXE3 of mouse origin
- recommended for detection of FOXE3 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-393526 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FOXE3 Antibody (G-1). This work is in progress.
FOXE3 Antibody (G-1) is a mouse monoclonal IgM antibody that detects FOXE3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FOXE3 antibody (G-1) is available as the non-conjugated form. FOXE3, consisting of 288 amino acids, is a member of the forkhead-box (FOX) gene family, which includes at least 43 distinct members. As a winged-helix transcription factor, FOXE3 is critically involved in the early stages of lens development, particularly in the closure of the lens vesicle, which is essential for proper eye formation. FOXE3 promotes the survival and proliferation of lens epithelial cells while preventing premature differentiation, ensuring that the lens maintains clarity and function. FOXE3 expression is restricted to the undifferentiated cells on the anterior surface of the lens as the posterior lens fiber cells begin to differentiate, highlighting FOXE3′s role in maintaining the balance between proliferation and differentiation during lens development. Mutations in FOXE3 can lead to congenital primary aphakia (CPA), a rare condition characterized by the absence of a lens, typically arising during the fourth or fifth week of human embryogenesis.
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FOXE3 Antibody (G-1) References:
- A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. | Blixt, A., et al. 2000. Genes Dev. 14: 245-54. PMID: 10652278
- Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. | Brownell, I., et al. 2000. Genesis. 27: 81-93. PMID: 10890982
- Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts. | Semina, EV., et al. 2001. Hum Mol Genet. 10: 231-6. PMID: 11159941
- Human FOX gene family (Review). | Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1495-500. PMID: 15492844
- Pathways regulating lens induction in the mouse. | Lang, RA. 2004. Int J Dev Biol. 48: 783-91. PMID: 15558471
- Expression of FoxE4 and Rx visualizes the timing and dynamics of critical processes taking place during initial stages of vertebrate eye development. | Zilinski, C., et al. 2004. Dev Neurosci. 26: 294-307. PMID: 15855758
- Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. | Yoshimoto, A., et al. 2005. Development. 132: 4437-48. PMID: 16162653
- Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. | Medina-Martinez, O., et al. 2005. Mol Cell Biol. 25: 8854-63. PMID: 16199865
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXE3 Antibody (G-1) | sc-393526 | 200 µg/ml | $322.00 | |||
FOXE3 (G-1) Neutralizing Peptide | sc-393526 P | 100 µg/0.5 ml | $69.00 | |||
FOXE3 Antibody (G-1) X | sc-393526 X | 200 µg/0.1 ml | $322.00 |