FMR1 Antibody (148.1): sc-101048

FMR1 Antibody (148.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FMR1 protein of mouse and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). FMR1 (148.1) antibody is available as the non-conjugated form. FMR1 protein, also known as Fragile X Mental Retardation Protein (FMRP), plays a crucial role in regulating synaptic plasticity and is essential for normal cognitive function. FMRP is primarily located in the cytoplasm, where FMRP associates with polyribosomes to facilitate transport and translation of specific mRNAs, thereby influencing protein synthesis in response to neuronal activity. This localization enables FMRP to modulate translation of proteins critical for synaptic development and function, particularly important in fragile X syndrome, the most common form of inherited intellectual disability. In fragile X syndrome, FMR1 gene undergoes transcriptional silencing due to CGG repeat expansion in its 5′ untranslated region, leading to FMRP deficiency. FMRP absence disrupts normal synaptic function and contributes to cognitive and behavioral challenges associated with the disorder. FMR1 (148.1) monoclonal antibody serves as an essential tool for researchers studying molecular mechanisms underlying fragile X syndrome and related disorders, as well as exploring broader implications of FMRP in neurodevelopmental processes.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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FMR1 Antibody (148.1) References:

1. Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.  |  Tamanini, F., et al. 1999. Biochem J. 343 Pt 3: 517-23. PMID: 10527928
2. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.  |  Ceman, S., et al. 1999. Mol Cell Biol. 19: 7925-32. PMID: 10567518
3. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.  |  Verkerk, AJ., et al. 1991. Cell. 65: 905-14. PMID: 1710175
4. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.  |  Matunis, MJ., et al. 1992. Mol Cell Biol. 12: 164-71. PMID: 1729596
5. Absence of expression of the FMR-1 gene in fragile X syndrome.  |  Pieretti, M., et al. 1991. Cell. 66: 817-22. PMID: 1878973
6. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.  |  Zhang, Y., et al. 1995. EMBO J. 14: 5358-66. PMID: 7489725
7. A point mutation in the FMR-1 gene associated with fragile X mental retardation.  |  De Boulle, K., et al. 1993. Nat Genet. 3: 31-5. PMID: 8490650
8. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.  |  Eberhart, DE., et al. 1996. Hum Mol Genet. 5: 1083-91. PMID: 8842725

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FMR1 Antibody (148.1) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-FMR1 Antibody (148.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FMR1 Antibody (148.1) Specifications

Alternate Product Name: FMRP

Product Clone Name: 148.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 121-221

Epitope Target: FMR1

Epitope Species: human

Product Reactivity/Detection: FMR1

Species Reactivity/Detection: mouse, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for FMR1 Antibody (148.1): N/A

The preferred FMR1 antibody is FMR1 Antibody (D-6): sc-518105.