FMO3 Antibody (C-1): sc-515042
- FMO3 Antibody (C-1) is a mouse monoclonal IgG2b κ FMO3 antibody provided at 200 µg/ml
- raised against amino acids 388-427 mapping within an internal region of FMO3 of human origin
- FMO3 Antibody (C-1) is recommended for detection of FMO3 of human origin by WB, IP, IF and ELISA
- Anti-FMO3 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for FMO3 Antibody (C-1) for WB applications. This reagent is now offered in a bundle with FMO3 Antibody (C-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FMO3 Antibody (C-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects FMO3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FMO3 antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FMO3, a member of the flavin-containing monooxygenase family, plays a crucial role in the metabolism of xenobiotics and drugs by catalyzing the N-oxidation of soft nucleophiles, particularly secondary and tertiary amines. This enzymatic activity is vital for the detoxification of various compounds, thereby influencing drug efficacy and safety. FMO3 is predominantly located in the liver, where FMO3 facilitates the oxidative metabolism of numerous therapeutic agents, underscoring its importance in pharmacology and toxicology. Notably, defects in the FMO3 gene can lead to trimethylaminuria, a metabolic disorder characterized by the accumulation of trimethylamine, resulting in a distinctive fishy odor in bodily secretions. Genetic mutations in FMO3 disrupt the normal N-oxidation process, highlighting the enzyme′s critical role in maintaining metabolic homeostasis and the potential consequences of its dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FMO3 Antibody (C-1) References:
- The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis. | Petalcorin, MI., et al. 2005. Gene. 346: 83-96. PMID: 15716098
- Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. | Koukouritaki, SB., et al. 2005. Mol Pharmacol. 68: 383-92. PMID: 15858076
- Fishy taint in chicken eggs is associated with a substitution within a conserved motif of the FMO3 gene. | Honkatukia, M., et al. 2005. Genomics. 86: 225-32. PMID: 15916878
- Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. | Krueger, SK. and Williams, DE. 2005. Pharmacol Ther. 106: 357-87. PMID: 15922018
- Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. | Hisamuddin, IM., et al. 2005. Cancer Epidemiol Biomarkers Prev. 14: 2366-9. PMID: 16214918
- Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. | Koukouritaki, SB. and Hines, RN. 2005. Pharmacogenomics. 6: 807-22. PMID: 16296944
- Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. | Dolan, C., et al. 2005. BMC Med Genet. 6: 41. PMID: 16324215
- Cloning and sequencing of flavin-containing monooxygenases FMO3 and FMO4 from rabbit and characterization of FMO3. | Burnett, VL., et al. 1994. J Biol Chem. 269: 14314-22. PMID: 8188717
- Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst. | Krause, RJ., et al. 1996. Arch Biochem Biophys. 333: 109-16. PMID: 8806760
- Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform. | Falls, JG., et al. 1997. Arch Biochem Biophys. 347: 9-18. PMID: 9344459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FMO3 Antibody (C-1) | sc-515042 | 200 µg/ml | $322.00 | |||
FMO3 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-524914 | 200 µg Ab, 40 µg BP | $361.00 | |||
FMO3 Antibody (C-1) AC | sc-515042 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FMO3 Antibody (C-1) HRP | sc-515042 HRP | 200 µg/ml | $322.00 | |||
FMO3 Antibody (C-1) FITC | sc-515042 FITC | 200 µg/ml | $336.00 | |||
FMO3 Antibody (C-1) PE | sc-515042 PE | 200 µg/ml | $349.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 488 | sc-515042 AF488 | 200 µg/ml | $364.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 546 | sc-515042 AF546 | 200 µg/ml | $364.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 594 | sc-515042 AF594 | 200 µg/ml | $364.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 647 | sc-515042 AF647 | 200 µg/ml | $364.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 680 | sc-515042 AF680 | 200 µg/ml | $364.00 | |||
FMO3 Antibody (C-1) Alexa Fluor® 790 | sc-515042 AF790 | 200 µg/ml | $364.00 |